Hoechst Aktiengesellschaft

Ramanujam Rajagopalan

Bansi Lal

Hans-Jochen Lang

Wolfgang Scholz

Heinrich Christian Englert

Richard H Rupp

Yatendra Khandelwal

Vijay A Aroskar

Samina A Dohadwalla

Anis S Dohadwalla

Rashida A Dohadwalla

Deceased AliHussein Dohadwalla

Rajeshwari Kannan

Ramesh Gidwani

Radha Panicker

Chinnakulandai Sankar

Described are guanidinocarbonyl isoquinolines of the formula I, ##STR1## wherein R(1) is hydrogen, (amino) (cyclo) (aryl)alk(en)yl (heteroaryl); R(2) is hydrogen, halogen, alkyl, or aryl; G is a radical of the formula VII: ##STR2## X(2), X(3) and X(4) are hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono) (di) (lower alkyl) (amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also a process for their preparation, their use as medicaments, and medicaments containing them for treating congestive heart failure, and arrhythmic conditions as well as cardioprotective agents in mammals.

Antiarrhythmic and cardioprotective substituted -1(2H)isoquinolines,

Labdanes of the formula ##STR1## a process for their manufacture, pharmaceutical preparations containing an effective amount of these compounds and their use for the manufacture of a pharmaceutical preparation for treatment of cardiovascular diseases and high intraocular pressure.

Labdanes and process for their preparation

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Bombay, India

Ramanujam Rajagopalan