University of Pennsylvania

The Wistar Institute

Ramana V Davuluri

Louise C Showe

Donald O'Rourke

Luke Macyszyn

Sharmistha Pal

Yingtao Bi

An isoform-level gene panel is disclosed that can accurately classify a glioblastoma subtype from a tumor sample. Such an isoform level gene panel comprises the 121 to 214 target isoforms identified in Table 1. Also disclosed are reagents for quantitatively detecting the expression or activity of the target isoforms of Table 1 in a patient sample. For example, such ligands can be PCR primer and probes sets. This isoform-level gene panel and reagents for detection of the isoforms are useful in an isoform-level assay for diagnosis of the molecular subtype of a glioblastoma in a patient. The assay employs algorithms and a novel computer program that performs the functions of FIG.. In one aspect, the assay is a high-throughput format.

Growing community of inventors

Haverford, PA, United States of America

Ramana V Davuluri