Intermune, Inc.

Liposome Technology, Inc.

Materials Modification Inc.

Materials Modifications, Inc.

Ramachandran Radhakrishnan

Tirumalai Srinivas Sudarshan

Leonid Beigelman

Scott D Seiwert

Lawrence M Blatt

Ronald S Vladyka

Vladimir Serebryany

Karl Kossen

Kenneth Sultzbaugh

Robert M Abra

Krishnaswamy Kasthuri Rangan

Sanjay Kotha

Paul J Mihalko

Carl T Redemann

Annie Yau-Young

Luke S Guo

Joseph G Montes

Francis J Martin

Michael John Cyr

Martin C Woodle

Cheryl Renee Verdecchio

Carl T Redmann

Sabine M Pyles

Mike Cyr

Sabine Marie-Francoise Boutet

Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.

Method of modulating stress-activated protein kinase system

A composition for in situ formation and/or expansion of a polymer-based hemostatic agent to control bleeding includes a suitable amount of a polymer or polymer-forming component, hydrogen peroxide or chemical(s) capable of forming hydrogen peroxide, or a combination of both, and a decomposing agent for hydrogen peroxide. The decomposing agent includes an endogenously or exogenously supplied catalyst (other than catalase), or both, and/or the polymer or polymer-forming component.

In situ formation of an artificial blockage to control bleeding by polymer expansion with hydrogen peroxide and platinum catalyst

A composition for in situ formation of an artificial blockage to control bleeding includes a suitable amount of a polymer-forming component, a suitable amount of a crosslinking agent, hydrogen peroxide, and a decomposing agent for hydrogen peroxide. The decomposing agent includes exogenous or endogenous catalase, or both.

In situ formation of an artificial blockage to control bleeding by polymer expansion with hydrogen peroxide

A method of preparing a metal nitride and/or metal oxynitride particulate material includes heating a stoichiometric mixture of a metal compound and urea at a temperature of about 400-1000&#xb0; C. for a predetermined time period in the presence of argon, nitrogen, or both. The particulate material produced includes nanoparticles, nanotubes, microparticles, powder, or a combination thereof.

Method of preparing metal nitride and/or metal oxynitride particulate material as nanoparticles, microparticles, nanotubes, bulk powder, and/or coatings from organometallic precursors, and precursors therefor

A capsule formulation of pirfenidone is provided that includes pharmaceutically acceptable excipients. In one embodiment, this capsule formulation is capable of sustaining desirable pharmacokinetic responses in a patient. Further provided are methods of treating fibrotic conditions and other cytokine-mediated disorders by administering pirfenidone capsules of such formulation to a patient in need.

Capsule formulation of pirfenidone and pharmaceutically acceptable excipients

A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. Also disclosed are formulated dosage forms including the disclosed pirfenidone.

Method for synthesizing pirfenidone

Granulate formulation of pirfenidone and pharmaceutically acceptable excipients

A multifunctional particulate material, fluid, or composition includes a predetermined amount of core particles with a plurality of coatings. The core particles have an average particle size of about 1 nm to 500 &#x3bc;m. The particulate material, fluid, or composition is capable of exhibiting one or more properties, such as magnetic, thermal, optical, electrical, biological, chemical, lubrication, and rheological.

Multifunctional particulate material, fluid, and composition

An airbag inflation apparatus includes a chamber for generating a gas to inflate an airbag. A valve, including a magnetic fluid and a source of magnetic field, preferably an electromagnet, is associated with the chamber for regulating the flow of the gas into the airbag. A sensor determines and feeds occupant information to the sensor.

Method and airbag inflation apparatus employing magnetic fluid

A device for generating power includes a fluid including magnetic particles. A source magnetizes the fluid thereby inducing rotations in the magnetic particles for creating a magnetic flux. The rotations of the magnetic particles induce an electromagnetic force in a coil associated with the fluid.

Magnetic fluid power generator device and method for generating power

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Fremont, CA, United States of America

Ramachandran Radhakrishnan