Dr. Reddy's Laboratories, Incorporated

Dr. Reddy's Research Foundation

Ramabhadra Sarma Mamillapalli

Om Reddy Gaddam

Prabhakar Chebiyyam

Rajender Kumar Potlapally

Mahender Rao Siripragada

Chandra Sekhar Batchu

Vyas Krishnamurthi

Madhusudan Gutta

Sreenivasa Rao Dharmaraja

Ra Jender Kumar Potlapally

Ra Ju Sirisilla

Balaram Mahanti Satish

Raju Srisilla

Vishnuvardhan Reddy Seella

Chinna Bakki Reddy Gade

The present invention relates to novel crystalline Form of 5-[4-[[3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]methoxy]benzyl]thiazolidine-2,4-dione potassium salt having the formula (I). The invention also relates to a pharmaceutical composition comprising the novel crystalline Form and a pharmaceutically acceptable carrier. The novel crystalline Form of the present invention is more active, as an antidiabetic agent than the hitherto known 5-[4-[[3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]methoxy]benzyl]thiazolidine-2,4-dione potassium salt. 

Crystalline form of 5-[4-[[3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]methoxy]benzyl]thiazolidine-2,4-dione potassium salt

This invention relates to novel polymorphic/pseudopolymorphic forms of 5-[4-[2[N-methyl-N-(2-pyridyl)amino]ethoxy]benzyl]thiazolidine-2,4-dione maleate having formula (I). The invention also relates to a pharmaceutical composition comprising the novel polymorphic form or their mixture and a pharmaceutically acceptable carrier. The polymorphic forms of the present invention are more active, as antidiabetic agent, than the hitherto known 5-[4-[2-[N-(2-methyl-N-(2-pyridyl)amino]ethoxy]benzyl] thiazolidine-2,4-dione maleate 

Polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl)amino[ethoxy]benzyl] thiazolidine-2,4-dione maleate and process for their preparation

The present invention relates to an improved process for the preparation of novel antidiabetic compounds having formula (1) where Rrepresents hydrogen or lower alkyl group and X represents hydrogen or halogen atom 

Process for the preparation of new antidiabetic agents

The present invention relates to pharmaceutically acceptable salts of compound of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

Pharmaceutically acceptable salts of phenoxazine and phenothiazine compounds

The present invention relates to an improved process for the preparation of novel antidiabetic compounds having formula (1) where R represents hydrogen or lower alkyl group and X represents hydrogen or halogen atom.

This invention relates to novel polymorphic/pseudopolymorphic forms of arginine salt of 3-&lsqb;4-&lsqb;2-(phenoxazin-10-yl)ethoxy&rsqb;phenyl&rsqb;-2-ethoxypropanoic acid, having the formula I shown below. The invention also relates to a pharmaceutical composition comprising the novel polymorphic form or their mixture and a pharmaceutically acceptable carrier. The polymorphic forms of the present invention are more active, as antidiabetic and hypolipidemic agent, than the novel 3-&lsqb;4-&lsqb;2-(phenoxazin-10-yl)ethoxy&rsqb;phenyl&rsqb;-2-ethoxypropanoic acid.

Polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them

An improved process for the preparation of 5-&lsqb;4-&lsqb;&lsqb;3-Methyl-4-oxo-3,4-dihydroquinazolin-2-yl&rsqb;methoxy&rsqb;benzyl&rsqb;thiazolidine-2,4-dione of formula (1) which comprises: reducing the compound of formula (2&prime;) where R represents a (C -C )alkyl group using Raney Nickel or Magnesium in alcohol having 1 to 4 carbon atoms or mixtures thereof, if desired reesterifying using sufphuric acid at a temperature in the range of 0&deg; C. to 60&deg; C. to obtain a compound of formula (3&prime;) wherein R is as defined above, hydrolyzing the compound of formula (3&prime;) wherein R is as defined above, by conventional methods to obtain the acid of formula (4), condensing the acid of formula (4) with N-methyl anthranilamide directly without any preactivation of the acid to produce the compound of formula (1) and if desired, converting the compound of formula (1) to pharmaceutically acceptable salts thereof by conventional methods.

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Hyderabad Telangana, India

Ramabhadra Sarma Mamillapalli