Firmenich Incorporated

Nereus Pharmaceuticals, Inc.

Other

Rama Manam

Andrew P Patron

Barbara Christine Potts

Chris Edano Noriega

Justin Colquitt

Katherine A McArthur

Helge Zieler

Justin Stege

Nathan Faber

Venkat Rami Reddy Macherla

Nicole Servant

Ta-Hsiang Chao

Saskia Theodora Cornelia Neuteboom

Jeffrey Robert Hammaker

Venkata Rami Reddy Macherla

Taotao Ling

Nicole Gonsalves

Tanya Ditschun

Christina Susanto

Emilia Avanes

Daniel K Olson

Provided herein include methods of making mogroside compounds, e.g., Compound 1, compositions (for example host cells) for making the mogroside compounds, and the mogroside compounds made by the methods disclosed herein, and compositions (for example, cell lysates) and recombinant cells comprising the mogroside compounds (e.g., Compound 1). Also provided herein are novel cucurbitadienol synthases and the use thereof.

Methods for making high intensity sweeteners

The present invention includes compounds having structural formula (I), wherein R1-R9 are as defined herein, or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.

Polypodoside sweet flavor modifier

Provided herein include methods of making mogroside compounds, e.g., Compound 1, compositions (for example, host cells) for making mogroside compounds, and the mogroside compounds made by the methods and compositions disclosed herein, compositions made by the methods (for example, cell lysates), and recombinant cells comprising the mogroside compounds (e.g., Compound 1).

Disclosed herein are compounds having structural Formula (I), or salts thereof. These compounds are useful as sweet tasting agents and/or sweetness enhancers. Also disclosed are compositions comprising the present compounds and methods of increasing the sweet taste of ingestible compositions. Furthermore, methods for preparing the compounds are also disclosed.

High intensity sweeteners

Disclosed herein are compounds of Formula (I) that include a sulfonate ester, ester or ether group. Compounds of Formula (I) can be included in pharmaceutical compositions, and can be used to treating and/or ameliorating a disease or condition, such as cancer, a microbial disease and/or inflammation.

Proteasome inhibitors

The present invention relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs from a compound of formula (V). 

Total synthesis of salinosporamide A and analogs thereof

Disclosed herein are novel spiro beta-lactone/gamma lactams for use in treating bacterial infections and cancer. The compounds are characterized by a terminal electron-withdrawing group such as a nitro group. Screening data shows antimicrobial activity against various bacterial cell lines, particularly gram-positive bacteria, and anti-cancer activity.

Anti-bacterial and anti-cancer spiro beta-lactone/gamma-lactams

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San Diego, CA, United States of America

Rama Manam