University of Pittsburgh

The United States Government As Represented by the Department of Veterans Affairs

University of Iowa Research Foundation

Rama K Mallampalli

Beibei Chen

Yuan Liu

Charleen T Chu

Paul B McCray, Jr

Lokesh Gakhar

Subramanian Ramaswamy

Jennifer Bartlett

A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II:

Chemical inhibition of the E3 ligase subunit FBXO7 confers neuroprotection and anti-inflammatory activity by stabilizing mitochondria

A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of:

Benzathine analogs

Described herein are compounds that disrupt the interaction between Fbxo48 and phosphorylated-AMPK.

Small molecule AMPK activators

A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II: wherein each of R-Ris independently H, halogen, optionally-substituted alkyl, amino, alkoxy or hydroxy;

A compound of Formula II, or a salt, ester, solvate, hydrate or prodrug thereof: where:

Compositions and methods for treating diseases and conditions

A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: 

A compound of Formula II, or a salt, ester, solvate, hydrate or prodrug thereof: where:Xis a branched or unbranched Calkyl, (CH)&#x2014;NH&#x2014;(CH), (CH)&#x2014;O&#x2014;(CH), or (CH)&#x2014;C(NH)&#x2014;(CH)&#x2014;NH&#x2014;(CH), where s, t and v are each, independently an integer from 1 to 5;A and B are each, independently, Caryl, Caryl-Calkyl, Cheteroaryl, or Cheteroaryl-Calkyl, each optionally substituted with 1, 2 or 3 independently selected Rgroups;C and D are each, independently, Ccycloalkyl, Ccycloalkyl-Calkyl, Cheterocycloalkyl, Cheterocycloalkyl-Calkyl, Caryl, Caryl-Calkyl, Cheteroaryl, or Cheteroaryl-Calkyl, each optionally substituted with 1, 2 or 3 independently selected Rgroups;each Ris, independently, halogen, Calkyl, Chaloalkyl, hydroxyl, Calkoxy, Chaloalkoxy, amino, Calkylamino, or di-Calkylamino; andnand pare each, independently, integers from 1 to 10.

FBXO3 inhibitors

A method for treating a respiratory injury or disease comprising: administering to a patient in need of treatment a pharmaceutical composition comprising a compound of general Formula I: 

Compositions and methods for treating respiratory injury or disease

Embodiments include compositions and methods for lower the surface tension of a liquid-air interface by contacting such interface with all or part of a PLUNC polypeptide.

Growing community of inventors

Sewickley, PA, United States of America

Rama K Mallampalli