Council of Scientific and Industrial Research

Nicholas Piramal India Limited

Ram Pratap

Satyawan Singh

Ram Chandra Gupta

Omkar Prasad Asthana

Arvind Kumar Srivastava

Anil Kumar Rastogi

Ramesh Chander

Sudhir Srivastava

Nitya Anand

Anil Kumar Dwivedi

Sunil Kumar Puri

Deepak Raina

Chandeshwar Nath

Ashok Kumar Khanna

Narinder Kumar Kapoor

Satyavan Singh

Savita Srivastava

Swarn Nityanand

Jagdishwar Sahai Srivastava

Shio Kumar Singh

Vikash Chandra Pandey

Pratima Srivastava

Guru Prasad Dutta

Harsh Pati Thapliyal

Amiya Prasad Bhaduri

Ashim Ghatak

Sukh Dev

Swati Ajay Piramal

Anju Puri

Ram Raghubir

Raghwendra Pal

Onkar Prasad Asthana

Hemant Kumar Singh

Nitya Nand

Mavurapu Satyanarayana

Narenda Singh

Puvvada Sri Ramachandra Murthy

Arwind Kumar Srivastava

Depak Raina

Girja Shankar

Raghavendra Pal

Dharmendra Pratap Singh

Francis Joseph Pinto

Brajendra Kumar Tripathi

Priti Tiwari

Alok Kumar Verma

Mukesh Srivastava

Amar Bahadur Singh

Himanshu Singh

The present invention provides novel substituted flavone derivatives which exhibit anti-hyperglycemic and antidyslipedemic activity. The invention also provides a method for controlling type II diabetes and associated hyperlipidemic conditions in a mammal by administering compound of the present invention and compositions containing these derivatives.

Oxy substituted flavones as antihyperglycemic and antidyslipidemic agents

A combination kit for the treatment of malaria caused by() having individual doses of an anti-malarial agent, 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I) in the form of capsules; individual doses of the anti-malarial agent, chloroquine in the form of tablets; and instruction material for the administration of the two anti-malarial drugs. The combination kit is particularly suited for a 6 days treatment regimen where the treatment is rendered by five tablets containing 500 mg of chloroquine phosphate (equivalent to 300 mg base), three to be taken on day one and one each on days two and three; and five capsules containing 25 mg of 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I), one each to be taken on days two to six.

Combination kit used in the treatment of malaria

The present invention provides an improved process for the preparation of Guggulsterones which comprises epoxidising 16-dihydropegnenolone acetate (16 DPA) by reacting 16DPA with hydrogen peroxide reagent adduct in the presence of a co-base in a polar solvent to obtain 3 &#x3b2; hydroxy-16 &#x3b1;, 17-oxido-5 pregnen-20-one, converting the 3 &#x3b2; hydroxy-16&#x3b1;, 17-oxido-5-pregnen-20-one by reacting with hydrazine in the presence of a strong base at refluxing temperature followed by oxidation to obtain desired guggulsterones viz. to 5, 17-(20)-cis and trans pregnadiene-3 &#x3b2;, 16-diol of the formula Ia and Ib.

Process for preparing guggulsterones

The present invention a novel use of primaquine derivative N-(3-ethylidinotetrahydrofuran-2-one)-N-(6-methoxy-8-quinolinyl)-1,4-pentanediamine in the treatment and controlling the spread of malaria. In particular, the present invention discloses a method of treatment of malaria by the use of primaquine derivative N-(3-ethylidinotetrahydrofuran-2-one)-N-(6-methoxy-8-quinolinyl)-1,4-pentanediamine as a gametocytocidal agent.

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The present invention provides new uses of Gugulipid, an ethyl acetate extract of the resin of the plant, for controlling or preventing cognitive dysfunction, hyperglycemia and some infective conditions of the skin and a method of preparing Gugulipid by agitating the resin in shake flask assembly or sonicating assembly and preparing a solid or a creamy dosage forms.

Method of treating a cognitive memory dysfunction using Gugulipid

The invention provides a method of using pregnadienones and pregnadienols represented by the structural formula (I) as shown herein belowWherein X&#x2550;OH or O or combination thereof and positioning of olefinic bonds are at 4(5); 5(6); 16(17); 17(20) or various combinations and said compounds containing at least one olefinic bond in or on their D-ring for the treatment of hyperlipidemic and hyperglycemic conditions in mammals, said method comprising administering an effective amount of the said compounds to the recipient mammals.

Method of treating hyperlipidemic and hyperglycemic conditions in mammals using pregnadienols and pregnadienones

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Lucknow, India

Ram Pratap