Council of Scientific and Industrial Research

Ram Kishor Verma

Madan Mohan Gupta

Suman Preet Singh Khanuja

Mahendra Pandurang Darokar

Anil Kumar Gupta

Sushil Kumar

Ajit Kumar Shasany

Sudeep Tandon

Anil Kumar Singh

Dharam Chand Jain

Rajendra Singh Bhakuni

Atul Prakash Kahol

Shiv Kumar Gupta

Ravi Prakash Bansal

Santosh Kumar Srivastava

Alok Kalra

Tiruppadiripuliyur Ranganathan Santha Kumar

Dharmendra Saikia

Raj Kishori Lal

Mansoor Alam

Merajuddin Khan

Anirban Pal

Chandeshwar Nath

Arun Kumar Kukreja

Amit Tewari

Subhash Chandra Singh

Digvijay Singh

Guru Das Bagchi

Govind Ram

Subash Chandra Verma

Suman Preet Khanuja

Shilpi Paul

Janardan Singh

Neeraj Jain

Guru Das Bagachi

Ankur Grag

Raghavendra Kumar Mishra

Subash Chandra Singh

Deeptanjali Sahoo

Anuraddha Kumar

Anupam Maurya

Dnyaneshwar Umrao Bawankule

Shikha Gupta

Neerja Pant

Vinay Kumar Khanna

Ashok Kumar Agrawal

The present invention relates to bioactive extracts its fractions and isolation of compound from. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D, Cholinergic (muscarinic) and Serotonergic (5HT) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-demethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and &#x3b1;-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkaloids of formula 1 and 2 from the leaves of. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions ofand in the isolated compounds &#x3b1;-yohimbine, reserpiline and in a mixture 10-demethoxyreserpiline and 11-demethoxyreserpiline in 1:1.5 ratios for treating psychosis without any extra pyramidal symptoms (EPS). 

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The invention provides a simple method for isolation of calliterpenone (16&#x3b1;,17 dihydroxy-3-oxo phyllocladane), a phyllocladane diterpenoid with the plant growth regulating properties, from plant genus

Process for the isolation of calliterpenone

The present invention relates to a cultivar of'CIM-Jeevan', producing high amount of herb, phyllanthin and hypophyllanthin, wherein said cultivar is developed through &#x3b3;-irradiation of superior germplasm, the said plant produces high amount of herbage yield ranging between 1.0-1.15 kg per sqm fresh total plant herb, possesses high vegetative erect growth with a height ranging between 60 to 65 cm, produces phyllanthin ranging between 0.70-0.77% in dry herb, produces hypophyllanthin ranging between 0.32-0.37% in dry herb, and shows seed germination of about 90%.

The present invention provides an improved process for the isolation of oleane compounds from the bark of(Roxb.). More particularly, the present invention relates to an improved process for the isolation of arjunic acid and its derivates from the bark of(Roxb.). The present invention further provides the identification of arjunic acid [1] and its derivatives as anticancer agent useful in the treatment of various types of cancer in humans.

Process for the isolation of oleane compounds isolated from the bark of arjun tree terminalia arjuna (Roxb.)

The present invention is related to the development of a novel, distinct high herb and artemisinin yielding genotype ofobtained through systematic marker assisted breeding followed by selection of uniform population in a methodical way wherein the genotype is distinct, uniform and stably maintainable by continuous rouging of off types in the population using DNA marker at early seedling stage from nursery itself and suitable for commercial cultivation.

High artemisinin yielding artemisia plant named 'CIM-arogya'

The invention provides a method for maximization of artemisinin yield of the plant , said method comprising sowing seeds of plant on raised bed nursery during second and third week of December and maintaining the moisture throughout; transplanting seedlings thus obtained bearing at least 5-15 leaves into the main field fertilized with fertilizer, preferably NPK &commat; 80,40,40 kg/ha to achieve a population density of 50,000 to 200,000 per ha followed by light irrigation in the second week of March and irrigation every fortnight thereafter; harvesting the crop four times by cutting the plant tops leaving 75-100 cm part of plant for further regeneration, the said harvests are performed in a manner that the first harvest is done in fourth week of May, second harvest in third week of July, third harvest in second week of September and fourth harvest in third week of October of each year; and at each harvesting time care is taken to care at least one green branch, and extracting artemisinin from the plant tissue immediately after each harvest.

Method for maximization of artemisinin production by the plant artemisia annua

The invention relates to a process for the isolation of compound scopoletin which is used as nitric oxide synthesis inhibitor from and other plant families, said process comprising extraction of dried powdered material of different plant parts with an aqueous acetonitrite solvent in the ratio of 1:5 for 6 to 8 hrs., concentration of the extracted solvent upto 30% of its original extract under vacuum, partitioning the concentrated extract with halogenated solvent to transfer scopoletin in the non-polar halogenated solvent, drying halogenated solvent over anhydrous sodium sulphate and evaporating the solvent, crystallizing the residues in methanol and filtering the crystals, concentrating the filtrate and chromatographed on silica gel, eluting scopoletin in chloroform methanol mixture; and crystallization of the fractions containing the scopoletin to get the pure scopoletin compound.

Process for the isolation of compound scopoletin useful as nitric oxide synthesis inhibitor

Growing community of inventors

Lucknow, India

Ram Kishor Verma