Council of Scientific and Industrial Research

Nicholas Piramal India Limited

Ram Chandra Gupta

Ram Pratap

Omkar Prasad Asthana

Nitya Anand

Anil Kumar Dwivedi

Satyawan Singh

Arvind Kumar Srivastava

Sunil Kumar Puri

Anil Kumar Rastogi

Ramesh Chander

Sudhir Srivastava

Deepak Raina

Ashok Kumar Khanna

Narinder Kumar Kapoor

Vikash Chandra Pandey

Shio Kumar Singh

Jagdishwar Sahai Srivastava

Satyavan Singh

Savita Srivastava

Swarn Nityanand

Amiya Prasad Bhaduri

Ashim Ghatak

Harsh Pati Thapliyal

Sukh Dev

Guru Prasad Dutta

Pratima Srivastava

Swati Ajay Piramal

Francis Joseph Pinto

A combination kit for the treatment of malaria caused by() having individual doses of an anti-malarial agent, 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I) in the form of capsules; individual doses of the anti-malarial agent, chloroquine in the form of tablets; and instruction material for the administration of the two anti-malarial drugs. The combination kit is particularly suited for a 6 days treatment regimen where the treatment is rendered by five tablets containing 500 mg of chloroquine phosphate (equivalent to 300 mg base), three to be taken on day one and one each on days two and three; and five capsules containing 25 mg of 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I), one each to be taken on days two to six.

Combination kit used in the treatment of malaria

The present invention a novel use of primaquine derivative N-(3-ethylidinotetrahydrofuran-2-one)-N-(6-methoxy-8-quinolinyl)-1,4-pentanediamine in the treatment and controlling the spread of malaria. In particular, the present invention discloses a method of treatment of malaria by the use of primaquine derivative N-(3-ethylidinotetrahydrofuran-2-one)-N-(6-methoxy-8-quinolinyl)-1,4-pentanediamine as a gametocytocidal agent.

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The invention provides a method of using pregnadienones and pregnadienols represented by the structural formula (I) as shown herein belowWherein X&#x2550;OH or O or combination thereof and positioning of olefinic bonds are at 4(5); 5(6); 16(17); 17(20) or various combinations and said compounds containing at least one olefinic bond in or on their D-ring for the treatment of hyperlipidemic and hyperglycemic conditions in mammals, said method comprising administering an effective amount of the said compounds to the recipient mammals.

Method of treating hyperlipidemic and hyperglycemic conditions in mammals using pregnadienols and pregnadienones

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Lucknow, India

Ram Chandra Gupta