Ranbaxy Laboratories, Inc.

Ranbaxy Laboratory Limited

Ram Chander Aryan

Yatendra Kumar

Anita Chugh

Kumar Hari Bhushan

Mohammad Salman

Jitendra Anant Sattigeri

Radhakrishnan Gowri Shankar

Ramnik Sharma

Ramesh Dandala

Jag Mohan Khanna

Vijay Kumar Handa

Chandra Has Khanduri

Neera Tewari

Bishwa Prakash Rai

Vikram Krishna Ramanathan

Satish Kumar Aryan

Parendn Dhirajlal Rathod

Gowri Shankar

Bhargav R Panyda

Pudi Giri Jagannadha Naidu

Anamika Mishra

Vikram Krishna Ramanthan

Jitendra Sattiegeri

Parendu Dhirajlal Rathod

The present invention provides a process for the preparation of asenapine maleate of Formula (I), comprising: intra-molecular cyclization of the intermediate of Formula (II) to obtain the intermediate of Formula (III) using aluminium halide. 

Process for the preparation of asenapine maleate

The present invention provides a process for the preparation of clopidogrel and its pharmaceutically acceptable salts thereof comprises the resolving racemic methyl alpha-5-(4,5,6,7-tetrahydro[3,2-c]thienopyridyl)(2-chlorophenyl)-acetate by the salt formation of methyl alpha-5-(4,5,6,7-tetrahydro[3,2-c]thienopyridyl)(2-chlorophenyl)-acetate with excess levorotatory camphor-10-sulfonic acid to get a maximum yield of camphor sulphonate salt of methyl S-(+)-alpha-5-(4,5,6,7-tetrahydro[3,2-c]thienopyridyl) (2-chlorophenyl)-acetate and transforming the camphor sulphonate salt to clopidogrel or its pharmaceutically acceptable salts thereof.

Process for the preparation of clopidogrel and its pharmaceutically acceptable salts

The present invention relates to substituted pyrrole derivatives, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms.

Substituted pyrrole derivatives and their use as HMG-CO inhibitors

The present invention relates to a cost effective and industrially advantageous process for the preparation of imipenem of high purity comprising the steps of treating an aqueous solution containing imipenem with an organic solvent, wherein the imipenem is not lyophilized; and isolating the pure crystalline imipenem monohydrate from the reaction mixture thereof.

Process for the isolation of crystalline imipenem

The optically active compound, R (&#x2212;)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-hydroxybenzenesulfonamide in good optical purity, a metabolite of the &#x3b1;-adrenergic blocking agent tamsulosin, and methods for the preparation thereof. Pharmaceutical compositions including the optically active compound and methods of treatment comprising administration of an effective &#x3b1;-adrenergic antagonistic amount of such compositions to mammals.

Tamsulosin derivative

The invention relates to particular hydroxyl and protected hydroxyl derivatives of compounds known to be useful as HMG CoA-reductase inhibitors. In particular, herein are provided hydroxyl and protected hydroxyl compounds of Formula I and their corresponding lactones.

HMG CoA-reductase inhibitors

The optically active compound, R(&#x2212;)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-hydroxybenzenesulfonamide in good optical purity, a metabolite of the &#x3b1;-adrenergic blocking agent tamsulosin, and methods for the preparation thereof. Pharmaceutical compositions including the optically active compound and methods of treatment comprising administration of an effective &#x3b1;-adrenergic antagonistic amount of such compositions to mammals.

A process for preparing certain cephalosporin antibiotics, namely, cefotaxime, cefetemet, and ceftriaxone sodium comprising acylation of 7-amino-3-cephem-4-carboxylic acid derivatives with 2-mercapto-5-methyl-1,3,4-thiadiazolyl-(Z)-2-(2-aminothiazol-4-yl)-2-metho xyiminoacetate having the formula: ##STR1##

Process for producing cephalosporin antibiotics

Growing community of inventors

New Delhi, India

Ram Chander Aryan