Phonoflow Medical, LLC

Ralph Walter Zaorski

Norman Lee Owsley

Roger Paul Norris

An apparatus for locating a source of vibrational cardiac energy within a human, includes a data processing system configured to accept vibrational cardiac data collected by at least three transducers during a plurality of heart cycles. A computer readable medium containing executable computer program instructions which, when executed by the data processing system, cause the data processing system to perform steps that include, performing a time-to-frequency transformation on the vibrational cardiac data acquired within at least a portion of the heart cycles. The time-to-frequency transformation is applied to the vibrational cardiac data acquired synchronously from each transducer to obtain a plurality of complex frequency spectra. The steps include identifying a vernier band (VB) of frequency associated with a feature derived from the plurality of complex frequency spectra. The vibrational cardiac data are processed over the VB of frequency to obtain a first vibrational cardiac energy level for a first location within the human's chest. The first location corresponds to a source of the first vibrational cardiac energy level.

Systems, apparatuses, and methods for locating blood flow turbulence in the cardiovascular system

A method of locating a source of vibrational cardiac energy within a human, includes acquiring time synchronized vibrational cardiac data noninvasively from a surface of the human's body with at least three transducer channels. A time-to-frequency transformation is performed on the vibrational cardiac data to obtain a sequence of heart cycle ensemble averaged power spectral density (PSD) estimates. A feature is identified in the PSD estimates. A vernier band (VB) in frequency is established for the feature. The VB portion of the PSI) estimates that correspond to the feature are processed to obtain a vibrational energy intensity level estimate at a spatial location within the human's body. A metric of clinical significance is obtained from the strength of the estimated vibration intensity within a VB and at a location relative to a background noise level.

Method and apparatuses are described to evaluate a state of health of a coronary artery. Vibrational cardiac data from a transducer is received from a first location. The transducer measures vibration of a surface of a human's body non-invasively. The vibrational cardiac data is processed in a second location to create processed vibrational cardiac data. The processing includes separating an unwanted coronary event from the vibrational cardiac data. The processing further includes performing a time-to-frequency transformation on the vibrational cardiac data from a portion of a diastolic interval within a heart cycle to obtain a vibrational frequency power spectrum estimate. The processing includes evaluating a state of health of the coronary artery using the processed vibrational cardiac data.

System and method for evaluating a state of health of a coronary artery

Methods and apparatuses are described to obtain cardiac data, which includes acquiring vibrational field cardiac data from a transducer wherein the transducer measures vibration over a surface of a human's body. An unwanted coronary event is separated from vibrational cardiac data. A transient event is extracted from the vibrational cardiac heart cycle data. The transient event occurs during a diastolic interval within a heart cycle. The transient event is evaluated for a condition of coronary artery blood flow turbulence and a condition of health of a coronary artery is assessed from a feature in the vibrational frequency power spectrum estimate.

Spectrum analysis of coronary artery turbulent blood flow

A method includes acquiring vibrational cardiac data from an array of N transducers wherein the transducers are coupled to a human. A master replica is selected from a segment of the vibrational cardiac data. The master replica is correlated with the segment to obtain a plurality of local maxima. Vibrational cardiac data that were emitted during a diastolic interval are extracted from each heart cycle with the aid of the plurality of local maxima. A two-dimensional space-time frequency power spectrum is processed for Equivalent Rectangular Bandwidth, which provides estimates of the energy produced by turbulent blood flow through a coronary stenosis.

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Davenport, FL, United States of America

Ralph Walter Zaorski