Applied Medical Resources Corporation

University of California

Other

Boston Scientific Scimed, Inc.

Scimed Life Systems, Inc.

Boston Scientific Corporation

Med Institute Incorporated

Vance Products Inc.

Cook Urological, Inc.

Urogen Pharma Ltd.

Ralph V Clayman

Gary R Dulak

Edward D Pingleton

Alyssa J Dassa

Douglas E Godshall

Christopher Fishbein

Charles C Hart

John R Brustad

Richard Christian Ewers

Said S Hilal

Frans Vandenbroek

Jaime Landman

Neal E Fearnot

Michael L Jones

Nabil Hilal

Steve R Lamb

Willet Francis Whitmore, Iii

Ghassan Sakakine

Frank Shi

Bounsavanh Pravongviengkham

Gary L Butler

Omer Tsipori

Michael Klopfer

Kam Kaler

Yeong-Her Lin

Donald R Hollinger

Yuan-Chang Lin

Willet F Whitemore, Iii

Pengbo Jiang

Mark Schoenberg

William C Collyer

Willett F Whitmore, Iii

Michael K Louie

Timothy G Vendrely

Willet F Iii Whitmore

Provided herein are methods for treating nephrolithiasis and protecting the urothelium and inner lining of the kidney from thermal damage during lithotripsy by use of a thermosensitive bio-adhesive hydrogel. The described method dramatically improved the efficiency and effectiveness of stone clearance compared to conventional techniques while providing protection to the urothelium from potentially damaging temperature spikes.

Thermosensitive bio-adhesive hydrogel for removal of ureteral and renal stones

The invention relates to medical devices and methods of use thereof, such as for example, ureteroscopy. In one embodiment, the device is a safety ureteral access sheath and interventional catheter insertion with a force meter and a force disengagement mechanism. In another embodiment, the invention provides a method of examination or treatment for a condition in a subject, comprising providing a device comprising a ureteral access sheath (UAS) operably linked to a force meter and a force disengagement mechanism, and using the device to examine or treat the subject.

Safety ureteral access sheath and interventional catheter insertion with intrinsic and extrinsic force meters

A ureteral access sheath adapted for insertion into a urethra includes an elongate tube extending between a proximal end and a distal end. A handle assembly is disposed at the proximal end and includes enlarged portions which inhibit migration of the sheath into the urethra. The enlarged portions are shaped like the bell of a horn with a concave, distally-facing outer surface and a convex, proximally-facing inner surface. The inner surface functions as a funnel while the outer surface is sized and configured to receive adjacent fingers of a user's hand held in its natural position. In an associated method, this shape of the handle assembly facilitates maintaining the sheath in a stationary position during insertion and removal of instrumentation. The handle assembly can be movable on the tube to facilitate variation of the sheath length.

Ureteral access sheath

A high-flow low-pressure irrigation system for directing a fluid to and recovering the fluid from an area within a body, the irrigation system comprising a sheath defining a sheath lumen and a flexible catheter disposed in and through the sheath lumen. The catheter defines a catheter lumen and comprises a plurality of apertures at a distal portion that curls in a pigtail configuration. The fluid is directed and outputted to the body area through the catheter lumen and the apertures, and the outputted fluid is recovered and returned through the sheath lumen.

High flow-low pressure irrigation system

A ureteral access sheath adapted for insertion into a urethra includes an elongate tube extending between a proximal end and a distal end. A handle assembly is disposed at the proximal end and includes enlarged portions which inhibit migration of the sheath into the urethra. The enlarged portions are shaped like the bell of a horn with a concave, distally-facing outer surface and a convex, proximally-facing inner surface. The inner surface functions as a funnel while the outer surface is sized and configured to receive adjacent fingers of a user's hand held in its natural position. In an associated method, this shape of the handle assembly facilitates maintaining the sheath in a stationary position during insertion and removal of instrumentation. The handle assembly can be movable on the tube to facilitate variation of the sheath link in situ.

A silicone composition having anti-microbial properties contains well distributed silica and nanoparticles of a noble metal. Silica and nanoparticles of a noble metal are added to liquid vinyl-terminated polydimethylsiloxane. A coupling agent is then added to the mixture and heated, the coupling agent comprising trialkoxysilane having a formula RSi(OR), wherein Ris vinyl or allyl, and Ris an alkyl radical having from 1 to 3 carbon atoms. In one embodiment, trimethylsiloxy terminated polymethylhydrosiloxane is then added to the mixture and heated in the presence of a catalyst so as to cross-link and cure the same into a silicone elastomer. In another embodiment, in place of the trimethylsiloxy terminated polymethylhydrosiloxane, a peroxide is added to mixture and heated to form the silicone. In this later example, no catalyst is needed.

Silicone composition and devices incorporating same

A ureteral stent for assisting movement of urine along a patient's ureter and into the patient's bladder. The stent includes an elongated tubular segment extending toward the bladder from a kidney end region for placement in the renal cavity to a bladder end region. A central lumen connects at least one opening at the first end region to at least one opening in the bladder end region. Thin flexible tail(s) are attached to the bladder end region of the tubular segment at a point outside the bladder so as to receive urine from the opening in the bladder end region and to transport urine from there across the ureter/bladder junction and into the bladder. The tails include an elongated external urine-transport surface configured to transport urine. The transporting surface(s) are configured to extend along at least part of the ureter, across the ureter/bladder junction, and into the bladder.

Ureteral stent with small bladder tail(s)

A ureteral stent for assisting movement of urine along a patient's ureter and into the patient's bladder. The stent includes an elongated tubular segment extending toward the bladder from a kidney end region for placement in the renal cavity to a bladder end region. A central lumen connects at least one opening at the first end region to at least one opening in the bladder end region. Thin flexible tail(s) are attached to the bladder end region of the tubular segment at a point outside the bladder so as to receive urine from the opening in the bladder end region of the tubular segment and to transport urine from there across the ureter/bladder junction and into the bladder. The tails include an elongated external urine-transport surface sized and configured to transport urine along the ureter. The urine transporting surface(s) are sized and configured to extend along at least part of the ureter, across the ureter/bladder junction, and from there into the bladder.

Medical device with tail(s) for assisting flow of urine

An electrosurgical instrument includes a handle with a hollow elongate configuration and an electrosurgical assembly having ends disposed within the hollow handle and forming a continuous loop moveable by operation of the handle between an enlarged state and a contracted state. An electrosurgical element included in the assembly has an outer surface and axis and a lumen extending along the axis. Transverse portions of the element define a plurality of slots extending transverse to the axis and providing fluid communication between the lumen and the outer surface of the element. The element includes an insulated backbone and a plurality of ribs disposed to extend in space relationship to each other transverse to the backbone. A method of manufacture includes the step of creating slots in the element to define the ribs in the backbone.

Electrosurgical snare

A urological guidewire includes a core formed of a first metallic material and extending toward an end of the guidewire. A coil having a plurality of convolutions is disposed around the core at the end of the guidewire, the coil being formed of a second metallic material different than the first metallic material. A mechanical interlock is formed to inhibit separation of the different materials forming the coil and the core. The mechanical interlock may include an enlargement at the end of the core and a bonding material fixing the enlargement to the coil. The convolutions may include a penultimate convolution with a first radius of curvature and an ultimate convolution having a second, shorter radius of curvature to form a bridge. In this case, portions of the core can be bent back on themselves and directed over or around the bridge to form the mechanical interlock.

Guidewire

Medical device with tail(s)

A drainage catheter is adapted to drain fluid from the body cavity through a body conduit and includes an elongate tube having a distal end and a retention member disposed at the distal end and adapted for movement between the low-profile state facilitating insertion of the catheter and a high-profile state facilitating the tension of the catheter in its operative position. A woven mesh forms at least a portion of one of the tube and the retention member, and can be made permeable or impermeable in various regions of the catheter. The woven mesh can be formed of filaments heat-settable so that the catheter automatically moves to the high-profile state. Insertion of the catheter can be facilitated using an obturator and a guidewire in an associated method, an obturator facilitating insertion of the catheter can be removed to permit the catheter to automatically return to a normal, high-profile state.

Drainage catheter

Growing community of inventors

Clayton, MO, United States of America

Ralph V Clayman