Global Life Sciences Solutions USA LLC

Ge Healthcare Bio-sciences Corp.

Cytiva Sweden Ab

Ge Healthcare Bio-sciences Ab

Ralph Stankowski

Eric Tenander

Ethan Michael Barrieau

Colin R Tuohey

Klaus Gebauer

Steven James Forsberg

Michael Miller

Richard Lee Damren

Jonathan A Kenney

Andreas Castan

Douglas Albagli

William Andrew Hennessy

Mats Olsson

Eric Faldt

Anders Wilen

Thomas Falkman

Anindya Kanti De

Nagaraj Raghavendra Rao

Matthew Ouellette

Camilla Estmer-Nilsson

Nirmal Kumar Thanikachalam

Anindya Sengupta

Hanna-Leena Saukkonen

Shanice Jones

Benjamin Brown

Lauren Lisle

Vincent Francis Pizzi

Jeffrey L Carter

Alexander Mark Kilar

Eric Fäldt

Hanna-leena Saukkonen

Michelle Ann Parziale

Yvette Klingberg

Asa Lundstrom

Manus Dash

Timothy Becker

Michelle Parziale

Alexander Kilar

Prasad Bagiyanathan

Nikhil Chandramouli

Timothy J Becker

A biocompatible polymeric membrane includes pores defined between two material layers, where the first membrane material layer includes strips, and the second membrane material binds to each of the plurality of first membrane material layer strips includes a plurality of windows exposing each of the first membrane material strips. The biocompatible polymeric filtration membrane comprises pores defined by uniform passages defined by the first membrane material layer strips and the second membrane material layer within each window.

Biocompatible polymeric filtration membrane with pores defined by uniform passages

The present invention relates to a bioprocess bagcomprising a bag wall defining an enclosed volume for holding biomaterials. The bag wall comprises at least one inlet portand at least one outlet port. The bioprocess bagalso comprises a tube structurecomprising a first opened-end proximate the bag wall and a second distal end, the tube extending into the enclosed volume, and the tube structurecomprising a reinforced portionproximate the first opened-end.

Reinforced component for cell cultivation bioreactor

A sparger device includes a sparge tube having opposed distal ends, an inlet opening, and a plurality of sparge holes along a longitudinal extent of the sparge tube between the opposed distal ends, and a central hub coupled with the sparge tube at a point intermediate the opposed distal ends of the sparge tube, the central hub having a fluid passageway in fluid communication with the sparge tube via the inlet opening.

Sparger device for a bioprocessing system and method of manufacturing a sparger device

A support housing for a flexible bioprocess bag, the housing comprising at least one side wall having a first segment and a second segment, the first segment movable in relation to the second segment between an open and a closed position, wherein at least a supporting part of the housing is translatable from an operating position to a bag loading position, wherein the supporting part comprises one or more retainers for holding the flexible bioprocess bag upon re-translation of the supporting part to the operating position and movement of the first segment to the closed position, and wherein the first segment comprises a first drive unit for connecting and driving a first mixing unit in the flexible bioprocess bag.

Housing for holding a flexible bioprocess bag and method for assembling the bag in the housing

Filter holders and membranes are provided that can be included within a bioreactor bag system. The filter holders and membranes include features that abut the bottom of the filter membrane and prevent or reduce sagging of the porous filter region during use.

Perfusion filter assembly for increased cross flow

A packaging for a bioprocessing bag includes a housing having an open interior space, and a support base attached to an external side of the housing, the support base having a recess for receiving an impeller base plate of a bioprocessing bag.

System and method for packaging a bioprocessing bag and associated components, and packaging for a bioprocessing bag

An apparatus for minimizing dead leg spaces in a container or tubing includes a first member having a flange for attaching the first member to a wall of the container or tubing, the flange having at least one aperture, and a second member rotatably coupled to the first member, the second member having an upper end having at least one aperture, and an open distal end. The second member is rotatable relative to the first member between a closed position where the at least one aperture of the second member is misaligned with the at least one aperture in the flange to prevent the passage of fluid, and an open position where the at least one aperture of the second member is aligned with the at least one aperture in the flange to allow for the passage of fluid.

System, method and apparatus for minimizing dead legs in a bioreactor system

Tangential flow cassette-HF emulation

A connection clamping device () arranged for securing a flexible tube () to a barbed end () of a tube connector (), whereby the barbed end () comprises a barb () and the tube connector during connection is arranged to protrude into an end of the flexible tube (), characterized in that said connection clamping device comprises two sections () which, during connection when the tube connector protrudes into an end of the flexible tube, are arranged to be connected and locked to each other by a locking mechanism () around the tube connector () and the flexible tube (), such that the flexible tube () is compressed against the tube connector () by a rib () provided on the inner circumference of the connection clamping device.

Connection clamping device

An apparatus for draining a bioreactor vessel includes a tubular body portion having an interior passageway, and at least one aperture in the tubular body portion providing for fluid communication with the interior passageway, the tubular body portion being configured for positioning at a bottom of a vessel, and a suction tube having a first end configured for fluid coupling with the tubular body portion, and a second end configured for fluid coupling with a port in a sidewall of the vessel.

System, method and apparatus for draining a bioreactor vessel

Housing for holding a flexible bioprocess bag

The invention discloses a flexible bag assembly for cultivation of cells, comprising one or more bags forming a plurality of cultivation compartments, wherein a drain port in at least a first cultivation compartment is adapted to be fluidically connected with a second cultivation compartment upon opening of a valve means. It also discloses a bioreactor with the bag assembly mounted on a rocking tray and a method of cultivating cells in the assembly.

Bag assembly for cultivation of cells

The present invention provides a system for the insertion of a pre-sterilized sensor probe into a sterile vessel. The system of the invention provides a reliable and straightforward way to insert one or more sterile probes into a sterile vessel. The present invention also provides a sterile vessel that includes one or more of the systems of the invention. The sterile vessel can be a flexible or semi-rigid bag or tubing of the type typically used for carrying out biochemical and/or biological processes and/or manipulating liquids and other products of such processes. Furthermore, the present invention provides a method for aseptically inserting a probe into a sterile vessel where the method makes use of the system of the invention.

Sterile sensor insertion

A connection clamping device comprising two halves which are arranged to be connected and locked to each other by a locking mechanism around the a flexible tube, such that the flexible tube is compressed by a rib provided on the inner circumference of the connection clamping device.

Growing community of inventors

Westborough, MA, United States of America

Ralph Stankowski