Schering Aktiengesellschaft

A/s Ferrosan

Shering Ag

Scherling Ag

Schering Aktiengeseellschaft

Ralph Schmiechen

Andreas Huth

Dieter Seidelmann

Dieter Rahtz

Herbert H Schneider

Mogens Engelstoft

David N Stephens

Helmut Biere

Wolfgang Kehr

Claus T Braestrup

Lechoslaw Turski

Dieter Palenschat

Gert Paschelke

Helmut Wachtel

John Bondo Hansen

Martin Kruger

Ulrich Eder

Gunter Neef

Olaf Loge

Ekkehard Schillinger

Wolfgang Losert

Clemens Rufer

Reinhard Horowski

Ralph Rohde

Hanns Ahrens

Frank Waetjen

Eberhard Schroeder

Peter Holscher

Peter A Loschmann

Tage Honore

Joergen A Christensen

Henning Schou

John S Andrews

Bondo John Hansen

Jogen A Christensen

Ingrid Schumann

Ilse Beetz

Mogens C Nielsen

Rudolf Wiechert

Bernd Muller

Karl Petzoldt

Leif H Jensen

Werner Krause

Guenter Neef

Erling N Petersen

Kurt Hamp

Rolf Russe

Matthias Gottwald

Preben Olsen

The disclosure relates to quinoxaline derivates of Formula I

Quinoxaline-carboxylic acid derivatives

The disclosure relates to quinoxaline derivatives of Formula I ##STR1## wherein R.sup.1, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are as defined in the disclosure, as well as their production and use in medicinal agents.

Quinoxaline-phosphonic acid derivatives

5- or 6-substituted .beta.-carboline-3-carboxylic acid esters of Formula I ##STR1## wherein R.sup.1 is hydrogen, nitrilo, halogen, lower alkyl or lower alkoxy, and

5- or 6-substituted .beta.-carboline-3-carboxylic acid esters

Compounds of formula I are described ##STR1## in which R.sup.3 represents a C.sub.6-12 -aryl or hetaryl radical, optionally substituted singly or multiply with C.sub.1-4 -alkyl, C.sub.3-7 -cycloalkyl, halogen, C.sub.1-4 -alkoxy-C.sub.1-2 -alkyl, phenyl or amino, the process for their production and their use in pharmaceutical agents.

3-aryl or 3-hetaryl-.beta.-carbolines, their production and use in

An enzymatic process employing pancreatin or choelsterol esterase for resolution of racemates of 4-aryl-2-oxo-pyrrolidine-3-carboxylic acid esters of general formula I ##STR1## in which X represents a carbon-carbon bond or an oxygen atom,

Process for resolution of racemates of

.beta.-carbolines of formula I are described ##STR1## in which R.sup.A is a C.sub.6-12 aryl hetaryl as defined herein, that can be substituted singly to multiply with halogen, C.sub.1-4 -alkoxy, C.sub.1-4 -alkyl or amino,

.beta.-carboline derivatives for use as pharmaceutical agents

.beta.-carboline-3-hydroxyalkylcarboxylic acid ester derivatives,

4-Isoxazolyl-imidazole derivatives of formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings indicated, as well as their production and use in pharmaceutical agents, are described.

Isoxazolylimidazole derivatives, process for their production and their

Beta-carbolines, process for their production and their use in

Compounds of general Formula I are disclosed ##STR1## wherein R.sup.1 is C.sub.1-4 -alkyl,

3,4-disubstituted phenyl heterocycles and their use

A .beta.-carbolin-3-carboxylic acid derivative of the formula ##STR1## wherein: X is oxygen, sulphur or NR.sup.10, wherein R.sup.10 is hydrogen, C.sub.1-6 -alkyl, C.sub.1-6 -alkenyl, C.sub.3-7 -cycloalkyl or C.sub.3-7 -cycloalkenyl;

.beta.-carbolin-3-carboxylic acid derivatives useful for treating

N-hetaryl imidazole derivatives of general Formula I ##STR1## are disclosed in which

N-hetaryl imidazole derivatives

Heteroaryloxy-.beta.-carboline derivatives of general Formula I ##STR1## wherein R.sup.1 is an optionally substituted heteroaryl residue,

Heteroaryloxy-.beta.-carboline derivatives, their preparation and their

Imidazole derivatives

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Berlin, Germany

Ralph Schmiechen