Schering Aktiengesellschaft

Ralph Rohde

Walter Elger

Sybille Beier

David A Henderson

Rudolf Wiechert

Ralph Schmiechen

Andreas Huth

Klaus Nickisch

Gunter Neef

Dieter Seidelmann

Klaus Annen

Herbert H Schneider

Helmut Biere

Dieter Rahtz

David N Stephens

Guenter Neef

Henry Laurent

Gerhard Sauer

Helmut Hofmeister

John Bondo Hansen

Eckhard Ottow

Alfred Weber

Mogens Engelstoft

Lechoslaw Turski

Wolfgang Losert

Jurgen Westermann

Michael Harre

Uwe Klages

John S Andrews

Mario Kennekke

Preben Olsen

Eckard Otto

A process for the production of 17-oxosteroids by fermentative oxidation of 17.beta.-hydroxy steroids is described, which is characterized in that for the fermentation, a bacterial culture of the species Mycobacterium spec. NRRL B-3805, Mycobacterium spec. NRRL B-3683, Mycobacterium phlei NRRL B-8154 or Mycobacterium fortuitum NRRL B-8153 is used.

Process for the production of 17-oxosteroids via the fermentative

2-iodo-3-keto-.DELTA..sup.4 steroids, process for their production, as

Imidazole derivatives of general Formula I ##STR1## wherein R.sup.1 means hydrogen, an optionally substituted C.sub.1-10 hydrocarbon or hetaryl residue, or a cyclic ether residue,

Imidazole derivatives

13-alkyl-11.beta.-phenyl-gonanes of general formula I ##STR1## wherein A and B together stand for an oxygen atom, a CH.sub.2 group or a second bond between carbon atoms 9 and 10,

11 .beta.-phenyl-gonanes, their manufacture and pharmaceutical

N-hetaryl imidazole derivatives of general Formula I ##STR1## are disclosed in which

N-hetaryl imidazole derivatives

A process is disclosed for the preparation of 4-alkoxyalkyl .beta.-carboline derivatives of general Formula I ##STR1## wherein R.sup.1 is hydrogen or methyl,

Process for the preparation of 4-alkoxyalkyl .beta.-carbolines

.beta.-Carbolines of general Formula I ##STR1## wherein Y represents the residue ##STR2## and R.sup.a and R.sup.b, being identical or different, mean respectively hydrogen, C.sub.1-6 -alkoxy, phenyl, C.sub.3-7 -cyclo-alkyl, optionally substituted C.sub.1-6 -alkyl or C.sub.1-6 -alkoxycarbonyl, and R.sup.c and R.sup.d, being identical or different, mean respectively hydrogen or C.sub.1-6 -alkyl or jointly a linkage, and

Isoxazole-.beta.-carboline derivatives

Descriptions are given of 11.beta.-aryl-estradienes of general formula I ##STR1## where X means an oxygen atom or a hydroxyimino group N.about.OH, where the hydroxy group may be in the syn or anti position,

11 Beta-N,N-dimethylaminophenyl-estradienes, their manufacture and

11.beta.-Arylestradienes of general Formula I are disclosed ##STR1## wherein R.sup.2 is a hydrogen atom, a methyl group, or an ethyl group,

11.beta.-arylestradienes, their production, and pharmaceutical

Compounds of the formula I ##STR1## wherein R.sub.1 is ##STR2## wherein R.sup.I and R.sup.II each independently is alkyl of 1-4 carbon atoms, or R.sup.I and R.sup.II together with the connecting N-atom form a 5- or 6-membered heterocyclic ring whose remaining atoms are all C-atoms, or which also includes and additional N-atom, an additional O or S atom or a combination thereof; ##STR3## wherein R.sup.I and R.sup.II are as defined above; --SR.sup.III, wherein R.sup.III is methyl, ethyl or phenyl; or

11.beta.-aryl estradienes, processes for their production and

Growing community of inventors

Berlin, Germany

Ralph Rohde