Merck + Co., Inc.

Other

Banyu Pharmaceutical Co. Ltd

Ralph P Volante

Ichiro Shinkai

David Askin

Paul J Reider

Kai Rossen

Joseph E Lynch

Ioannis N Houpis

Audrey Molina

Philip J Pye

Richard John Varsolona

Sander G Mills

Woo-Baeg Choi

David M Tschaen

William L Laswell

Kan K Eng

Thomas R Verhoeven

Kenneth M Wells

Steven A Weissman

Edward G Corley

James M McNamara

Ann E DeCamp

Richard Desmond

Jess Sager

Meyer Sletzinger

Toshiaki Mase

Thomas M Liu

Anthony O King

Daniel Richard Sidler

Robert A Reamer

Todd K Jones

Ilias K Dorziotis

Kenji Maeda

Andrew S Thompson

Guy R Humphrey

David J Mathre

Peter Emmanuel Maligres

Toshihiro Wada

Guo-Jie Ho

George G Hazen

Takehiko Iida

Roger N Farr

Jaemoon Lee

James J Bergan

Mahadevan Bhupathy

Kenichi Asakawa

Ashok Maliakal

Matthew Heileman

Alan T Kawaguchi

Daisy Joe

Hiroki Sato

Hywyn R Churchill

Peter G Houghton

Nobuyoshi Yasuda

Robert D Larsen

Ian W Davies

Shinji Kato

Michel M Chartrain

Kenneth M Ryan

Kenneth E Wilson

R Scott Hoerrner

Alan W Douglas

Veena Upadhyay

Jean-Francois Marcoux

Robert K Anderson

Robert M Purick

Michael A Wallace

Meyer Sleteinger

Fengrui Lang

Joannis Houpis

This invention relates to a process for making spirolactone compounds analogous to formula I. 

Process for making spirolactone compounds

This invention relates to a process for making spirolactone compounds analogous to formula I 

Michael addition conducted in the presence of a zinc-amine complex and additional amounts of the amine component results in product with high diastereomeric excess.

Diastereoselective preparation of Michael adducts

Process for the synthesis of carbapenem intermidiates, and compounds produced

The present invention relates to a process for the preparation of a compound of formula (I) or a sodium salt thereof

Process for the preparation of leukotriene antagonists

A process for making a beta methyl carbapenem intermediate is disclosed. A compound of formula I:

Preparation of betamethyl carbapenem intermediates

An improved process using chiral hydrogenation is described for the synthesis in high yields of a 4-protected-(S)-piperazine-2-tert-butylcarboxamide, an intermediate for an HIV protease inhibitor.

Process for preparing

The invention encompasses a process for making compounds of Formula I or Ia useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1##

Intermediates for making heterocycles useful as COX-2 inhibitors

The instant invention relates to a compound of the formula: ##STR1## wherein R.sub.a and P are: (a) hydrogen,

Preparation of beta-methyl carbapenem intermediates

The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.

Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2

The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1##

This invention relates to a sulfate salt of an HIV protease inhibitor, Compound A, of formula: ##STR1## Compound A is useful in the treatment of AIDS, ARC or HIV infection in adults and children. Processes for making the sulfate salt of Compound A are also disclosed.

HIV protease inhibitor

The present invention is directed to a novel convergent process for the preparation of the compound N-[1(R)-[(1,2-dihydro-1-methanesulfonyl-spiro[3H-indole-3,4'-piperdin]-1'- yl)carbonyl]-2-(phenylmethyl-oxy)ethyl]-2-amino-2-methyl-propanamide, and salts thereof, which has the structure: ##STR1## and which has the ability to stimulate the release of natural or endogenous growth hormone. This compound may be used to treat conditions which require the stimulation of growth hormone production or secretion such as in humans with a deficiency of natural growth hormone or in animals used for food or wool production where the stimulation of growth hormone will result in a larger, more productive animal.

Convergent process for the preparation of a growth hormone secretagogue

New chiral biphosphines, e.g., ##STR1## are useful as key components in catalysts for asymmetric reactions, providing desirably high enantiomeric excess (ee).

Chiral bisphosphines

Process for the preparation of a growth hormone secretagogue

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Cranbury, NJ, United States of America

Ralph P Volante