Astra Aktiebolag

Aktiebolaget Draco

Aktiebolaget Astra

Ralph Lennart Brattsand

Bror Arne Thalen

Bengt I Axelsson

Arne Thalen

Jan W Trofast

Stinabritt Nilsson

Peter Edman

Thomas Hogberg

Paul Andersson

Jan Erik Ulmius

Rikard Holmdahl

Carl Magnus Dahlback

Paul H Andersson

Per T Andersson

Lars Pettersson

Leif Kallstrom

Leif Arne Kallstrom

Marjana Loncar

Leif A Kallstrom

Liselotte Jansson

Novel compounds which are a glucocorticosteroid (GCS) chemically bound to a sugar, having the general formula

Colon or ileum-specific glucocorticosteroid derivatives

Estrogens

Disclosed are processes for preparing the 22R and 22S epimers of the compound ##STR1## The processes involve acetalization, transacetalization, hydrolysis (of an ester) or hydrogenation (of a diene) of an appropriate starting material. Also disclosed are pharmaceutical compositions comprising the compounds produced by the processes and methods of treatment of inflammatory and allergic conditions employing the compounds.

Processes for the production of anti-inflammatory steroids

Colon or ileum-specific steroid derivatives

The invention concerns compounds of formula I ##STR1## in which R.sub.1 is hydrogen or a straight or branched hydrocarbon chain; R.sub.2 is hydrogen or a straight or branched hydrocarbon chain; R.sub.3 is acyl; X.sub.1 is hydrogen, fluorine or chlorine; and X.sub.2 is hydrogen, fluorine or chlorine. Also disclosed are processes for preparation of the compounds, pharmaceutical compositions containing them and methods employing the compounds in the treatment of inflammatory and allergic conditions.

Steroid esters

Fluorinated steroids

The invention refers to compounds having activity against inflammatory, allergic, and dermatological conditions. The compounds are characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula R.sub.1 is selected from a straight or branched hydrocarbon chain having 1-4 carbon atoms. The invention also refers to processes for the preparation of these compounds, pharmaceutical preparations containing one of the compounds and a method for the treatment of inflammatory, allergic, muscoskeletal and dermatological conditions.

16,17-acetalsubstituted pregnane 21-oic acid derivatives

The invention refers to compounds having anti-inflammatory activity, characterized by the formula ##STR1## in the form of a stereoisomeric mixture or an epimer of the R or S type regarding the orientation of the substituents in the carbon atom at position 20, in which formula the 1,2 position is saturated or is a double bond,

Novel androstane-17.beta.-carboxylic acid esters, a process and

Pharmaceutical composition for administration primarily to the respiratory tract when treating and controlling anti-inflammatory conditions comprising liposomes in combination with a compound of the formula ##STR1## and R.sup.1 is a saturated or unsaturated, straight or branched alkyl group with 11-19 carbon atoms and R is H, --COCH.sub.3, --COC.sub.2 H.sub.5, --CO(CH.sub.2).sub.2 CH.sub.3 or --CO(CH.sub.2).sub.3 CH.sub.3.

Liposomes containing steroid esters

The invention refers to compounds having anti-inflammatory activity, characterized by the formula ##STR1## in the form of a stereoisomeric mixture or an epimer of the R or S type regarding the orientation of the substituents at the carbon atom in position 22, in which formula A is n-propyl or n-butyl and Z is hydroxyl or hydroxyl esterified with a fatty acid with a straight or branched hydrocarbon chain having 1-5 carbon atoms. The invention also refers to a process for the preparation of these compounds, a pharmaceutical preparation containing one of the compounds and a method for the treatment and control of inflammatory conditions.

4-Pregnene-derivatives, a process for their preparation, composition and

Growing community of inventors

Lund, Sweden

Ralph Lennart Brattsand