Oklahoma State University

University of Oklahoma

Ralph Lazzara

Benjamin J Scherlag

Kenneth D Berlin

Subbiah Sangiah

Eugene S Patterson

Gregory Lynn Garrison

Chun-Lin Chen

George Edward Burrows

Cyril Roy Clarke

Warren M Jackman

3,7-Diazabicyclo�3.3!nonanes and selected derivatives thereof of the general formula: ##STR1## wherein Q=S; Z=CH.sub.2 ; and Y equals an N-acyl or N-alkyl group are disclosed as multiclass antiarrhythmic agents.

N-alkyl and N-acyl derivatives of 3,7-Diazabicyclo-�3.3.1!nonanes and

3,7-Diazabicyclo[3.3.1]nonanes and selected derivatives thereof of the general formula: ##STR1## are disclosed as multiclass antiarrhythmic agents.

N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and

A system for aborting the dual pathway tachycardias in a heart comprising the syndrome of paroxysmal supraventricular tachycardia (due generally to atrioventricular nodal reentry or atrioventricular reentry using an anomalous atrioventricular connection for retrograde conduction) by sensing cardiac impulses and, with respect to each sensed cardiac impulse, determining if such sensed cardiac impulse is an inciting cardiac impulse, a cardiac impulse which occurs at a time with respect to the last received cardiac impulse which falls within a predetermined echo zone and which will result in the initiation of a dual pathway tachycardia, and inducing an aborting cardiac impulse in response to a sensed inciting cardiac impulse in the cardiac muscle at a time within the predetermined aborting zone for aborting the initiation of the dual pathway tachycardia. The system also contemplates sensing cardiac impulses and delivering aborting electrical stimuli at a particular position on the cardiac muscle to allow more accurate recognition of inciting cardiac impulses and for more effectively delivering the aborting electrical stimulus, inducing the aborting cardiac impulse in sufficient time to abort the onset of dual pathway tachycardia.

System for prevention of paroxysmal supraventricular tachycardia

Growing community of inventors

Oklahoma City, OK, United States of America

Ralph Lazzara