Auckland Uniservices Limited

Ralph James Stevenson

William Alexander Denny

William Robert Wilson

Graham John Atwell

Adam Vorn Patterson

Moana Tercel

Shangjin Yang

David C Ware

Frederik Bastlaan Pruijn

Jared Bruce Milbank

The present invention relates generally to nitro-1,2-dihydro-3H-benzo[e]indoles and related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

Nitrobenzindoles and their use in cancer therapy

This invention relates to a class of heterocycles and their metal complexes, and is particularly concerned with the use of these compounds in the preparation of prodrugs or as prodrugs that may be activated under hypoxic conditions by enzymes or by therapeutic ionising radiation, in the treatment of cancer. The invention also relates to the use of these heterocycles and the corresponding metal complexes in the preparation of medicaments and to compositions including the heterocycles or their metal complexes and to methods for preparing these compounds.

Anti-cancer 2,3-dihydro-1H-pyrrolo[3,2-f]quinoline complexes of cobalt and chromium

Growing community of inventors

Auckland, New Zealand

Ralph James Stevenson