Other

Integra Lifesciences Corporation

Ralph-Heiko Mattern

Amy E Wright

Robert S Jacobs

Michael D Pierschbacher

Juerg F Tschopp

Timothy Irvin Malaney

Fred Cahn

Compositions of cross-linked collagen and a glycosaminoglycan are provided which retain characteristics rendering them useful as tissue engineering matrices or scaffolds following terminal sterilization. Also provided are methods for producing these compositions and terminally sterilized matrices or scaffolds from these compositions as well as methods of using these matrices or scaffolds as tissue engineering devices.

Collagen/glycosaminoglycan matrix stable to sterilizing by electron beam radiation

Novel uses of biologically active bis-heterocyclic e.g. bis-indole alkaloid compounds which have improved activity are disclosed. Pharmaceutical compositions containing the compounds are also disclosed. Specifically, the novel Utility pertains to the anti-immunogenic and neurogenic inflammatory properties exhibited by the bis-indole compounds and their analogs.

Synthetic compounds for treatment of inflammation

Novel uses of biologically active bis-heterocyclice.g. bis-indole alkaloid compounds which have improved activity are disclosed. Pharmaceutical compositions containing the compounds are also disclosed. Specifically, the novel utility pertains to the anti-immunogenic and neurogenic inflammatory properties exhibited by the bis-indole compounds and their analogs.

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San Diego, CA, United States of America

Ralph-Heiko Mattern