Dsm IP Assets B.v.

Ralph Haerter

Werner Bonrath

Reinhard Karge

Ulla Letinois

Alexander Radspieler

Ulrike Lemke

Process for the manufacture of a compound of the structure (I) with R=hydrogen, alkyl (C1-C10, linear, cyclic or branched, aliphatic or aromatic), NR'R&#x2033; (wherein R&#x2032; and R&#x2033; are independently selected from H, alkyl [C1-C10, linear, cyclic or branched, aliphatic or aromatic] and R=CHRwherein Ris selected from NHR1&#x2032;&#x2033; (with R&#x2032;&#x2033;=C(O)H, C(O)CH, C(O)alkyl, CHCH(OMe)or other saponifiable residues), alkyl (C1-C10, linear, cyclic or branched) aromatic residues, heteroaryl residues, substituted aryl residues, e.g. 3,4,5-trimethoxy-phenyl) wherein 1 equivalent of an &#x3b1;-formyl-propionitrile salt is reacted with 0.75 to 2 equivalents of an acetamidine salt in the presence of a Lewis acid. 

Synthesis of 4-amino-pyrimidines scaffolds

A novel process for the preparation of resveratrol and piceatannol and esters thereof involving a Heck type reaction is disclosed. Also disclosed are novel intermediates in that process.

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Biel-Benken, Switzerland

Ralph Haerter