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Rhein Biotech Gesellschaft Fur Neue Biotechnologische Prozesse Und Produkte Mbh

Ralph H Pries

Alexander Wm Strasser

Gerd Gellissen

Dae-Jin Yoon

Gerhard Braus

Kim Yoon-Ok

Dae-Hin Yoon

Sven Krappmann

Yoon-Ok Kim

The invention relates to a nucleic acid molecule, comprising a nucleic acid which codes for a polypeptide with chorismate mutase activity and derivatives thereof, whereby the derivatives have at least 10% of the chorismate mutase activity of the chorismate mutase, according to the identification number of the SEQ ID NO:2. The invention further relates to vectors containing nucleic acid molecules, to host cells comprising nucleic acid molecules and their use in methods for producing polypetides with chorismate mutase activity. The invention also relates to the polypeptides with chorismate mutase activity and antibodies which specifically recognize the same. In addition, the invention relates to methods for producing auxotrophic yeast strains using the nucleic acid molecules and to the preparation of the yeast strains. The invention also relates to the use of yeast strains together with the inventive vectors in methods for the recombinant expression of heterologous genes which allow the transformants to be easily selected by functional complementation.

Nucleic acid molecule, comprising a nucleic acid coding for a polypeptide with chorismate mutase activity

Modified semiconductor laser diode having an integrated temperature

Device for the qualitative and/or quantitative determination of the

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Dortmund, Germany

Ralph H Pries