American Cyanamid Company

Ralph G Child

Yang-I Lin

Joseph J Hlavka

Panayota Bitha

Raymond G Wilkinson

Andrew S Tomcufcik

Stanley A Lang, Jr

Ving J Lee

Keith C Murdock

John F Poletto

Adolph E Sloboda

Dennis W Powell

Thomas L Fields

Yang I Lin

Leslie H Sutherland

Organic platinum complexes active as anti-tumor agents in warm-blooded animals, and methods for synthesis of same, are described.

(Gem-heterocyclodimethanamine-n,n&prime;)platinum complexes

Organic-platinum complexes useful as anti-cancer agents in the treatment of tumors sensitive to the subject compounds are described.

(2,2-bis(aminomethyl)-1,3-propranediol-N,N')platinum complexes

(Gem-heterocyclodimethanamine-N,N')platinum complexes

Novel organic compounds of the formula ##STR1## where R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl(C.sub.1 -C.sub.6); or R.sub.1 and R.sub.2 taken together are selected from the group consisting of ##STR2## where n is an integer 3-6, ##STR3## where m is an integer 3-6, and ##STR4## and L is selected from the group consisting of --O--, --CH.sub.2 --, ##STR5## and &gt;NR.sub.3 where R.sub.3 is alkyl(C.sub.1 -C.sub.6) or --CH.sub.2 CH.sub.2 OH, which have antineoplastic activity, compositions containing the compounds and methods of using the compounds to treat tumors in mammals.

Platinum complexes of amines with novel dibasic acids

Substituted 4-quinoline-carboxylic acids useful in the treatment of arthritis and inhibition of progressive joint deterioration are disclosed together with methods of use and synthesis thereof.

2-Phenyl-4-quinoline carboxylic acids

Novel organic-platinum compounds selected from those of the formulae: ##STR1## wherein L and L' are selected from the group consisting of halide, nitrate, sulfate and a monobasic carboxylate such as acetate or hydroxy acetate or L and L' taken together are a dibasic carboxylate selected from the group consisting of ##STR2## oxalic acid, methylmalonic acid, succinic acid and tartronic acid, or L and L' taken together are a tribasic carboxylate selected from the group consisting of ##STR3## taken together is ascorbic acid and X is selected from the group consisting of halogen and hydroxy.

(2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes

This disclosure describes platinum complexes of heterocyclic-1,2-diamines which possess the property of inhibiting the growth of tumors in mammals.

Heterocyclic-1,2-diamine platinum complexes

Platinum complexes and Di- or Tricarboxylic acids which is then reacted with the appropriate di- or tricarboxylic acid in aqueous medium.

Platinum complexes of diamino-dideoxy sugars and di- or tricarboxylic

This invention concerns novel 3,6-bis(substituted) acridine N-oxides and N,N-dioxides which are active as modulators of the immune system in warm-blooded animals.

3,6-bis (substituted) acridine N-oxides and N,N-dioxides and methods of

Novel organic compounds of the formula ##STR1## Where R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl(C.sub.1 -C.sub.6); or R.sub.1 and R.sub.2 taken together are selected from the group consisting of ##STR2## where n is an integer 3-6, ##STR3## where m is an integer 3-6, and ##STR4## and L is selected from the group consisting of --O--, --CH.sub.2 --, ##STR5## where R.sub.3 is alkyl(C.sub.1 -C.sub.6) or --CH.sub.2 CH.sub.2 OH, which have antineoplastic activity, compositions containing the compounds and method of using the compounds to treat tumors in mammals.

Platinum complexes of amines with dibasic acids

Platinum complexes of aliphatic tricarboxylic acids useful for inducing regression and/or palliation of cancer diseases in mammals.

Platinum complexes of aliphatic tricarboxylic acids

Platinum complexes of polyhydroxylated alkylamines and 2-polyhydroxylated alkyl-1,2-diaminoethanes useful for inducing regression and/or palliation of cancer diseases in mammals.

Platinum complexes of polyhydroxylated alkylamines and

This disclosure describes certain substituted 9,10-bis(2-aminoethoxy)anthracenes which are useful as modulators of the immune response system in warm-blooded animals and for inducing the regression of tumors in such animals.

9,10-Bis(aminoalkoxy)anthracenes

This disclosure describes 9,10-dihydroanthracene-9,10-dicarboxaldehyde-bis-hydrazones and derivatives thereof useful as antibacterial agents, for inhibiting the growth of transplanted mouse tumors, and for inducing the regression and/or palliation of leukemia and related cancers in mammals.

Bis(2-imida

This disclosure describes benzanthracene-5,12(or 7,12)-dicarboxaldehyde-bis-hydrazones and the 5,12(or 7,12)-dihydrobenzanthracene-5,12(or 7,12)-dicarboxaldehyde-bis-hydrazones useful as antibacterial agents, for inhibiting the growth of transplanted mouse tumors, and for inducing the regression and/or pallation of leukemia and related cancers.

Growing community of inventors

Pearl River, NY, United States of America

Ralph G Child