Eli Lilly and Company

Ralph E Kastner

Robert L Hamill

Karl H Michel

LaVerne D Boeck

Kay F Koch

Ronald D Johnson

Marvin M Hoehn

David S Fukuda

Jon S Mynderse

Otis W Godfrey

Robert L Hamil

Harold R Papiska

New peptide antibiotic A54145, individual A54145 components A, A.sub.1, B, B.sub.1, C, D, E and F and their pharmaceutically acceptable salts, are useful antibacterial agents which also improve growth performance in animals, especially poultry. Biologically pure cultures of the A54145-producing Streptomyces fradiae cultures NRRL 18158, NRRL 18159 and NRRL 18160 cultures and methods of making antibiotic A54145 using those cultures are also provided.

A54145 antibiotics and process for their production

Antibiotic A42125, which is produced by a new strain of Nocardia aerocolonigenes, NRRL 18049, is a useful inhibitor of Gram-positive and methane-generating microorganisms. A42125 also increases feed utilization efficiency in ruminants. A biologically purified culture of N. aerocolonigenes NRRL 18049 and a method for producing A42125 by fermentation of this culture are provided.

Pure culture of antibiotic A42125-producing strains of Nocardia

Antibiotic A42125 and process for its production

Antibiotic A41030, a complex of 7 individual factors, is produced by submerged, aerobic fermentation of new Streptomyces virginiae NRRL 12525, and Streptomyces virginiae NRRL 15156. The antibiotic factors are separated and possess antibacterial activity against Staphylococcus and Streptococcus species which are penicillin resistant. In addition, the antibiotic factors have shown inhibition of Streptococcus pneumonia Park I. The complex and the individual factors enhance feed efficiency in ruminant animals, and are growth promoters in chickens and swine, and are especially valuable in milk production in dairy cattle.

Microbial production of A41030 antibiotics

Antibiotic A47934 is produced by submerged, aerobic fermentation of new Streptomyces toyocaensis NRRL 15009. The antibiotic is active against gram-positive bacteria in vitro and in vivo. It promotes growth in poultry and swine and serves to enhance feed efficiency in ruminant animals having a developed rumen.

A47934 antibiotic and process for production thereof

Antibiotics

A new antibiotic of the rifamycin class, A39079 factor S-1, which has the structure ##STR1## is an effective broad-spectrum antibiotic and increases feed-utilization efficiency in animals.

Antibiotic A39079 factor S-1

A41030 Antibiotics

Antibiotic A41030, a complex of 7 individual factors, is produced by submerged, aerobic fermentation of new Streptomyces virginiae NRRL 12525, and Streptomyces virginiae NRRL 15156. The antiobiotic factors are separated and possess antibacterial activity against Staphylococcus and Streptococcus species which are penicillin resistant. In addition, the antibiotic factors have shown inhibition of Streptococcus pneumonia Park I. The complex and the individual factors enhance feed efficiency in ruminant animals, and are growth promoters in chickens and swine, and are especially valuable in milk production in dairy cattle.

A41030 antibiotics

A47934 Antibiotic and process for production thereof

Antibiotic A54556, a complex of 8 individual factors, produced by submerged, aerobic fermentation of new Streptomyces hawaiiensis NRRL 15010. The complex and the individual, separated factors are active against Staphylococcus and Streptococcus which are penicillin resistant.

A54556 Antibiotics and process for production thereof

Antibiotic A-39183 complex, comprising microbiologically active, related factors A, B, C, D, and E, is produced by submerged, aerobic fermentation of a new microorganism Streptomyces sp., NRRL 12049. The A-39183 antibiotics are closely related antibiotics. The individual A-39183 factors are separated by chromatography. The A-39183 factors are antibacterial agents which have activity against Staphylococcus and Streptococcus species that are penicillin resistant. The A-39183 factors are also active against both gram-positive and gram-negative anaerobic bacteria, and are ionophores.

A-39183 Antibiotics and process for production thereof

The new microorganism Streptomyces granuloruber, NRRL 12389 and the fermentation process for preparing narasin by submerged aerobic fermentation of this organism.

Growing community of inventors

Indianapolis, IN, United States of America

Ralph E Kastner