Gen-probe, Inc.

Arthrex, Gmbh

Value Plastics, Inc.

Joerns Healthcare Limited

Ibalance Medical, Inc.

Nordson Corporation

Ralph E Burns

Robert Edwin Schneider

Kelly G Ammann

Ernest V Hansberry

Glenn A Horner

Robert J Smith

John E Kling

Cheryl A Jakub

Donald J Nieglos

Vincent P Novak

Richard W Cairns

Raymond L Townsend

James D Pisula, Jr

Jeffrey P Jensen

Michael C Moses

Justin R Taber

Annunziato Amendola

Amendola Ned

An apparatus and method for performing an open wedge osteotomy. The apparatus includes devices for forming an open wedge osteotomy in bone, including a keyed-wedge implant. The method includes the steps of forming a cut in a bone, forming a keyhole in the bone surface at the proximal end of the cut, and positioning a keyed wedge-shaped implant into the cut formed into the bone.

Apparatus for performing an open wedge, high tibial osteotomy

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

Automated analyzer for performing a nucleic acid-based assay

An automated method for detecting the presence of a nucleic acid in a sample, where the method is performed within a housing of a self-contained, stand-alone analyzer. The method includes purifying the nucleic acid after it has been immobilized on a magnetically-responsive solid support. A pipette of the analyzer is used to form a reaction mixture comprising the purified nucleic acid and all reagents required to perform a nucleic acid amplification. Amplification products are synthesized that include a nucleotide sequence contained in the nucleic acid or the complement of the nucleic acid. The amplification products are exposed to a probe in a mixture, where the probe forms a hybrid with one of the amplification products. The formation of the hybrid in the mixture provides an indication of the presence of the nucleic acid in the sample.

Method for detecting the presence of a nucleic acid in a sample

A method and apparatus for performing an open wedge osteotomy utilizing a keyed, wedge-shaped implant for disposition in a keyed, wedge-shaped opening created in a bone. The keys may be disposed in vertical or horizontal arrangements. In addition, a shear rib key hole may be formed adjacent the wedge-shaped opening in the bone.

Method and apparatus for performing an open wedge osteotomy

Method and apparatus for performing an open wedge, high tibial osteotomy

Apparatus for performing an open wedge, high tibial osteotomy, the apparatus comprising a wedge-shaped implant for disposition in a wedge-shaped opening created in the tibia, wherein the wedge-shaped implant comprises at least one key for disposition in at least one corresponding keyhole formed in the tibia adjacent to the wedge-shaped opening created in the tibia, wherein each of the at least one keys comprises an interior bore for receiving a fixation screw, at least one fixation screw for disposition in the interior bore of the at least one key, and further wherein the apparatus is configured so that when the at least one fixation screw is received in the interior bore, the at least one fixation screw terminates within the bore.

Apparatus for performing an open wedge, high tibial osteotomy, the apparatus comprising: A method for performing an open wedge, high tibial osteotomy, the method comprising:

An automated process for isolating and amplifying a target nucleic acid in a self-contained analyzer.

Method for performing an assay with a nucleic acid present in a specimen

An automated method for performing multiple nucleic acid amplification procedures in multiple receptacles of a set of receptacles contained in an analyzer.

Method for simultaneously performing multiple amplification reactions

An automated method for preparing and amplifying a sequence contained in a nucleic acid present in a sample, the nucleic acid being prepared in a receptacle that is part of a unit that includes a plurality of receptacles and holds a removable contact-limiting element for aspirating a fluid component of the sample from the receptacle.

Apparatus for performing an open wedge, high tibial osteotomy, the apparatus comprising: a wedge-shaped implant for disposition in a wedge-shaped opening created in the tibia, wherein the wedge-shaped implant comprises a hole extending therethrough; a fixation screw for extending through the hole and securing the wedge-shaped implant to the tibia; and a locking mechanism for releasably locking the fixation screw to the wedge-shaped implant. The fixation screw comprises: a shaft having a distal threaded portion and a proximal threaded portion, wherein the distal threaded portion and the proximal threaded portion are characterized by different thread pitches.

A latching female tubing coupler comprises an opening, a collet finger, and an actuation member. The opening is adapted to guide a male connector along a first line of action as the male connector passes into the opening to be received within the latching female tubing coupler. The collet finger includes an engagement feature adapted to engage a coupling feature of the male connector and displace along a second line of action generally normal to the first line of action. The actuator member is adapted to displace along a third line of action generally normal to the first and second lines of action in order to disengage the engagement feature from the coupling feature of the male connector. When the engagement feature is engaged with the coupling feature on a male connector, a fluid conduit of the male connector is held in fluid communication with a fluid conduit of the latching female tubing coupler.

Latching female fluid tubing coupler

Apparatus for performing an open wedge, high tibial osteotomy, the apparatus comprising:

Method for performing an open wedge, high tibial osteotomy, utilizing an apparatus comprising a wedge-shaped implant for disposition in a wedge-shaped opening created in the tibia, wherein the wedge-shaped implant comprises at least one key for disposition in at least one corresponding keyhole formed in the tibia adjacent to the wedge-shaped opening created in the tibia, wherein each of the at least one keys comprises an interior bore for receiving a fixation screw, at least one fixation screw for disposition in the interior bore of the at least one key, and further wherein the apparatus is configured so that when the at least one fixation screw is received in the interior bore, the at least one fixation screw terminates within the bore.

Growing community of inventors

Boulder, CO, United States of America

Ralph E Burns