Aspiair Gmbh

Chiracon Gmbh

Chelac Holding Gmbh

Ralf Zuhse

Dmytro Ostrovskyi

Heinrich Wieland

Marc A Kessemeier

Karlheinz Nocker

The invention relates to a method for the preparation of cannabidiol and an intermediate for the preparation of cannabidiol, wherein two intermediates are obtained, namely a silylated olivetol and a silylated olivetol (2) and brominated olivetol (4) which are stable, storable and which do not have undesirable properties or byproducts.

Method for the preparation of cannabidiol

The invention relates to a method for the production of acetylsalicylic acid lysinate, optionally lysine acetylsalicylate.glycine, comprising the following steps: a) providing a solution of acetylsalicylic acid in ethanol; b) providing an aqueous solution of lysine; c) combining the solutions of step a) and b) to form a mixture; d) optionally stirring the mixture; e) adding acetone to the mixture; f) incubating the mixture, to allow the formation of a acetylsalicylic acid lysinate product; g) isolating the acetylsalicylic acid lysinate product; wherein acetylsalicylic acid is used in excess compared to lysine and wherein no seed crystals are added to the mixture; and optionally the following further steps: h) providing a recrystallized glycine; wherein the glycine has been recrystallized with the following steps: h1) dissolving glycine in water; h2) adding acetone to the glycine solution; h3) stirring the mixture until a precipitate is obtained; i) combining the recrystallized glycine of step h) with the acetylsalicylic acid lysinate product of step g) to obtain lysine acetylsalicylate.glycine (LASAG) particles.

Synthesis of lysine acetylsalicylate glycine particles

The invention relates to the use of a steroid-3-carboxylic acid ester, a steroid-4 carboxylic acid ester or a steroid-17 carboxylic acid ester of a steroid, selected from the group of androstanones, androst-4-ene-diones, androst-5-ene-diones, dehydroepiandrosterones, androstenetriones or testosterones, with an acyl group of the carboxylic acid ester where R is selected from alkyl with at least two carbon atoms or cycloalkyl, or with the use of a compound containing these steroid carboxylic acid esters for local topical application for cosmetic or dermatological purposes. Moreover, this invention also relates to steroid carboxylic acid esters and their compounds used for local topical application.

Steroid carboxylic acid esters, compositions containing steroid carboxylic acid esters, and use of said compositions in local topical applications for cosmetic or dermatological purposes

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Berlin, Germany

Ralf Zuhse