Dynamic Biosensors Gmbh

Bayerische Motoren Werke Aktiengesellschaft

Roche Diagnostics Oeprations, Inc.

Ralf Strasser

Ulrich Rant

Andreas Langer

Dieter Heindl

Michael Schraeml

Paul Andreas Hampel

Herwin Daub

Ismajli Fjolla

Johannes Reusch

Hanna Beike

Paul Hampel

A method for characterizing the interaction between a protein and a small molecule by detecting a change in fluorescence emitted by a fluorescent dye and a nucleic acid structure which can be used in said method.

Method for detecting and/or characterizing the interaction between proteins and small molecules

The present invention relates to a method for detecting and/or characterizing molecular interactions between two molecules, in particular two proteins and most particular between an antigen and an antibody by using an immobilized single-stranded nucleic acid molecule to which single-stranded nucleic acid molecules having a ligand attached thereto are hybridized.

Method for detecting molecular interactions using an immobilized nucleic acid

The present invention relates to a method of identifying a nucleotide at a defined position and determining the sequence of a target polynucleotide using an electro-switchable biosensor, as well as devices comprising an electro-switchable biosensor and uses thereof.

Molecular dynamic sequencing

The present invention is directed to sequencing of nucleic acids. A method is provided for sequencing based on immobilized nucleic acid on a surface. Advantageously, a long range detection mechanism is used for detecting, whether a nucleotide provided to the substrate of a biochip has been incorporated into the immobilized template nucleic acid. Various different alignment means are provided by the present invention which can be used for facilitating a rigidly locking of the orientation of the DNA complex, which complex comprises the template nucleic acid, the primer and the capture nucleic acid. Various different linker systems may be used to immobilize the DNA complex at a first and a second strand end, such that the desired alignment of the DNA complex is achieved. Also co-adsorbed molecules on the substrate surface can be used for such an aligning measure. Additionally, or alternatively, an electrical field may be applied for repelling the DNA complex from the electrode and for facilitating a vertical DNA complex orientation. Advantageously, label-free nucleotides can be used, if desired.

Method for sequencing a template nucleic acid immobilized on a substrate

A device for measuring the filling level of a fuel tank, in particular for motor vehicles, having two openings for installation of a filling connection and a pump unit, and a film sensor provided with an electric connecting cable which can be connected to a display device through the pump unit. The film sensor is embedded in a protective tube which is provided with inlet openings for the fuel. The protective tube is mounted on the filling connection at the side and can be inserted jointly with it into the respective opening in the fuel tank.

Device for measuring the level of a fuel tank

A drive-away blocking device is provided for motorcycles having a side support. A sensor, which is mounted on the vehicle and has a linearly guided distance sensing device, and a control component, which is rigidly connected with the swivellable side support and which, at a site eccentric with respect to the axis of rotation of the side support, is connected by way of a restricted guidance with the distance sensing device of the sensor, are provided. In the operational support position of the side support, the sensor emits a signal to the electric or electronic engine control unit to prevent a driving-away of the motorcycle.

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Munich, Germany

Ralf Strasser