Koninklijke Philips Corporation N.v.

Robert Boschgmbh

Focus Surgery, Inc.

Sonacare Medical, LLC

Albert Einstein College of Medicine

Other

Bracco Suisse Sa

Sonablate Corp.

Robert Bosch Corporation Corp of Delaware

Ralf Seip

William Tao Shi

Jeffry E Powers

Narendra T Sanghvi

Roy S Carlson

Wo-Hsing Chen

Balasundar Iyyavu Raju

Russell C Watts

Evgeniy Leyvi

Aleksandra Popovic

David Paul Noonan

Chandan Guha

Mark Carol

Russell James Fedewa

Terrence James Sweeney

Yannick Bohren

Emmanuel Jean-Marie Gaud

Artur P Katny

Jean-Marc Paul Robert Hyvelin

Rodrigo Chaluisan

Francois Guy Gerard Marie Vignon

Dan Voic

Paul W Mikus

Feng Yan

John Douglas Fraser

Christopher Stephen Hall

Marcel Arditi

Stephen W Decker

Kenji Yamashita

Jacques M Dulin

Jonathan Thomas Sutton

Anthony P Corrado

Scott William Dianis

Russell J Fedewa

Helle Ullerup

Kris A Dines

Adam Morris

Davy Maria Willibrordus Schaeken

Todd Nicholas Erpelding

Sonia Souza

Jose Manuel Inocencio Azevedo

Sarah Rhoades Baxter

Clint C Weis

Shuhei Kagosaki

Yutaka Shimazaki

Bernard J Esarey

Francois Tranquart

Ebeline Bihel

Steven W Decker

Roy F Carlson

Jonathon Thomas Sutton

Laura Court

Maarten Johan Frido Rincker

Juliana Pauline Kelly

Richard Pfile

Michael A Penna

Jeffry Earl Powers

Jean-Marc Paul Hyvelin

Roy Francis Carlson

François Tranquart

Clint S Weis

A therapeutic ultrasound method configured to adaptively transmit ultrasound pulses toward microbubbles in a treatment region to remove an occlusion is described. In some examples, the system may include a treatment pulse unit configured to transmit an ultrasound pulse to a treatment region of a subject, the treatment region including a plurality of microbubbles. An echo detection unit may be configured to receive one or more echoes responsive to the ultrasound pulse. In some examples, the method may also include a data processor configured to identify, using data associated with the echoes, at least one echo signature indicative of a dynamic state of the microbubbles in response to the ultrasound pulse. A controller may be configured to adjust one or more parameters of an additional ultrasound pulse transmitted to the treatment region via the treatment pulse unit based on the at least one echo signature.

Adaptive pulsing for sonothrombolysis treatment

A therapeutic ultrasound system transmits a staggered or interleaved pattern of therapy beams for use in sonothrombolysis and other Vascular Acoustic Resonators (VAR) mediated therapy. The inventive technique minimizes VAR, e.g. microbubble, destruction due to adjacent beams, ensures uniform sonication of the targeted region by filling in the spaces between the beams in subsequent passes, and further provides a means for bubble replenishment to maximize the clot lysis from ultrasound. The technique is also applicable to diagnostic ultrasound, VAR mediated drug delivery and blood brain barrier opening.

Interleaved beam pattern for sonothhrombolysis and other vascular acoustic resonator mediated therapies

A fluid management system for use with an ultrasound probe assembly can include first and second conduits each configured to extend from and be fluidly connected to the ultrasound probe assembly. A fluid directing system can include a circulation pump fluidly connected to both the first and second conduits. A fluid degassing system can be fluidly connected to the first and second conduits. The fluid degassing system can be configured to remove at least some gas from the fluid in the ultrasound probe assembly. A temperature control system can be fluidly connected to the first and second conduits. The temperature control system can be configured to control the temperature of the fluid in the ultrasound probe assembly. A volume adjustment system can be fluidly connected to the first and second conduits. The volume adjustment system can be configured to adjust the volume of the fluid in the ultrasound probe assembly.

System and method for treating tissue, fluid management system, and ultrasound system including and/or for use with same

The present disclosure describes a therapeutic ultrasound system configured to adaptively transmit ultrasound pulses toward microbubbles in a treatment region to remove an occlusion. In some examples, the system may include a treatment pulse unit configured to transmit an ultrasound pulse to a treatment region of a subject, the treatment region including a plurality of microbubbles. An echo detection unit may be configured to receive one or more echoes responsive to the ultra sound pulse. In some examples, the system may also include a data processor configured to identify, using data associated with the echoes, at least one echo signature indicative of a dynamic state of the microbubbles in response to the ultrasound pulse. A controller may be configured to adjust one or more parameters of an additional ultrasound pulse transmitted to the treatment region via the treatment pulse unit based on the at least one echo signature.

An apparatus for patient-specific adjusting of ultrasound output pressure includes a controller () configured for adjusting, based on an estimate of thickness of a temporal bone () in a head of a medical treatment recipient, a pressure setting. It may also be based on treatment depth (). Ultrasound at the adjusted pressure setting is applied. A user interface may be provided for user entry of the estimate, the user interface being further configured for user indication of the treatment depth. Both the entered estimate and the indicated treatment depth may be used in calculating ultrasound attenuation (). The user indication can be interactive by virtue of designating, on a display, a location of a treatment target. The calculated attenuation may be a value, in decibels, that is in a range from 0.9&#xd7;(2.70&#xd7;0.1+16.60&#xd7;T+0.87&#xd7;(D&#x2212;T&#x2212;0.1)+3.02) to 1.1&#xd7;(2.70&#xd7;0.1+16.60&#xd7;T+0.87&#xd7;(D&#x2212;T&#x2212;0.1)+3.02), where T is the estimate in centimeters and D is the treatment depth in centimeters.

Setting of sonothromobolysis ultrasound output power

An apparatus for ultrasound irradiation of a body part () includes a first ultrasound transducer (), and a second ultrasound transducer () mounted oppositely, and is configured: a) such that at least two ultrasound receiving elements, for determining a relative orientation of the first to the second transducer, are attached to the first transducer; b) for a beam, from the first transducer, causing cavitation, and/or bubble destruction of systemically circulating microbubbles, within the body part; or c) both with the attached elements and for the causing. The apparatus registers, with said first transducer, the second transducer, by using as a reference respectively the features a) and/or b). A detachable subsystem includes either a therapy or imaging transducer, to form a combination imaging and therapy system, the subsystem being configured for removable coupling to correspondingly an imaging or therapy subsystem comprising a head frame () to which is mounted an imaging or therapy transducer, the imaging or therapy subsystem for registering the imaging or therapy transducer, one to the other, by the above method.

Transducer placement and registration for image-guided sonothrombolysis

Ultrasonic sonothrombolysis systems to produce two acoustic pressure levels of insonation during stroke therapy, mid/high acoustic pressure insonation directed to the site of a blood clot where microbubbles are present to induce microbubble-mediated blood clot lysis, and low acoustic insonation directed to the region surrounding the site of the blood clot where microbubbles are present to stimulate microvascular reperfusion of the surrounding tissue. The systems simultaneously produce blood clot lysis at the site of an occlusion and stimulate reperfusion of tissue affected by the occlusion.

Devices and methods for the ultrasound treatment of ischemic stroke

A method of performing a coronary bypass procedure is performed by a flexible apparatus controlled by at least one controller, the method may include acts of: percutaneously situating the flexible apparatus into a first artery coupled to connective tissue of a chest wall; transluminally detaching at least a portion of the first artery from the connective tissue by applying ultrasound signals of a first type emitted by at least one transducer of the flexible apparatus; steering at least a portion of the detached portion first artery from a current location to a bypass location at a target artery by applying a force transmitted through the flexible apparatus situated within the first artery; and coupling, by the flexible apparatus situated within the first artery, the first artery to the target artery at the bypass location to establish flow communication between the first artery and the target artery.

System for performing intraluminal coronary and method of operation thereof

An infusion system for sonothrombolysis treatment uses a syringe loaded with a microbubble solution and operated by a syringe pump to deliver the microbubble solution to a subject during sonothrombolysis treatment. To prevent the stratification of the microbubble solution in the barrel of the syringe during treatment, the barrel also contains a plurality of magnetic beads which are agitated into semi-random patterns of motion in the syringe chamber during the procedure. The magnetic beads are moved by magnetic attraction and repulsion from the moving magnets of a magnetic stirrer mounted in proximity to the syringe during treatment.

Infusion system and method for sonothrombolysis stroke treatment

An apparatus that performs a bypass procedure includes a steerable body portion and at least one transducer controlled by at least one controller. The system may include one or more acts of transluminally detaching at least a portion of a first artery from connective tissue of a chest wall that is attached to the first artery by applying ultrasound signals of a first type emitted by the at least one transducer situated within the first artery; steeling the detached portion of the first artery from a current location to a bypass location by applying a force from the steerable body portion, which is located outside of the first artery, to at least a portion of the detached portion of the first artery; and coupling the first artery to a target artery at the bypass location to establish flow communication between the first artery and the target artery.

System for performing extraluminal coronary bypass and method of operation thereof

A method for delivering ultrasound can include positioning at least a focal zone of a transducer of an ultrasound probe proximate to targeted tissue of a patient. The method can include supplying power to the transducer to deliver ultrasound energy from the transducer to a first portion of the targeted tissue for a predetermined amount of time to create a first focal lesion in the targeted tissue. The method can include at least temporarily ceasing power to the transducer so as to at least temporarily cease delivery of ultrasound energy from the transducer to the targeted tissue. The method can include supplying power to the transducer to deliver ultrasound energy from the transducer to the targeted tissue at least substantially continuously and along a predefined treatment path.

System, apparatus and method for high-intensity focused ultrasound (HIFU) and/or ultrasound delivery while protecting critical structures

An ultrasonic intracranial sonothrombolysis pressure amplitude is pre-quantified by using an ultrasound-scanner control unit () having an increasing and/or decreasing mode and designed for: with respect to a current mode, interrogating a blockage site iteratively so as to progressively and respectively increase or decrease a pressure amplitude of ultrasound being emitted to the site at which bubbles () for oscillating that is caused by the emitted ultrasound are present; iteration to iteration, deriving, from echoes of the emitted ultrasound, a magnitude of an energy of a signal; and automatically identifying, for the quantifying, an iteration that, in comparison with a just-previous iteration, fails to increase the magnitude. The interrogating may span a region that contains or goes through: the obstruction; another part of the blood vessel; and bubble circulation within a neighboring vessel and a neighboring capillary (). The deriving can be based on an ultraharmonic signal, with band-pass filtering being utilized to extract the ultraharmonic signal from returning signals differenced to remove stationary content.

Microbubble signal based temporal-bone thickness compensation for sonothrombolysis

A head frame for a medical patient includes support for a probe and a neck support. The frame wraps around the head of the patient and can be used in the supine position. The support may include a probe holder slidable under the head and configured to contact or engage the neck support. In some embodiments, conformal shaping to the head and/or neck of the patient, the frame's rigid construction, the alignment of the optionally separable holder to the neck support, the weight of the head, or a combination thereof serve to keep the distal tip of the ultrasound probe in place against the temporal region of the head without need for attaching the frame to the head as by straps, which may provide an arrangement robust against patient/vehicle movement in an emergency medical services setting.

Ultrasound head frame for emergency medical services

A device for delivery of a substance () using energy to protect, at a site of activation, against a side effect of another substance () that was delivered, is being delivered, and/or will be delivered, at another site. The activation may be non-invasive, remote and the energy beam () may be an ultrasound beam. A first of the substances can be activated at a particular energy level, and the second is then activated at a lower level so that a population of particles bearing the first substance is not inadvertently activated during activation of the second substance. The device may comprise a system to control the levels of energy applied.

Ultrasound mediated delivery with critical-organ protection

A method of diagnosis and treatment of tumors using High Intensity Focused Ultrasound is provided. The method of diagnosing the presence of a tumor in a patient comprises the steps of subjecting a tumor to high intensity focused ultrasound (HIFU) to cause the tumor cells to release cellular material and evaluating the cellular material for a tumor marker. The method of treating a tumor in a patient can also comprise the step of subjecting a tumor to high intensity focused ultrasound (HIFU) to provoke an immune response.

Method of diagnosis and treatment of tumors using high intensity focused ultrasound

Growing community of inventors

Carmel, NY, United States of America

Ralf Seip