Boehringer Ingelheim Microparts Gmbh

Miltenyi Biotec, Gmbh

Microparts Gmbh

Steag Microparts Gmbh

Miltenyi Biotec B.v. Co., Kg

Boehringer Ingelheim International Gmbh

Bayer Healthcare LLC

Siemens Healthcare Diagnostics Gmbh

Owl Biomedical, Inc.

Robert Boschgmbh

Hewlett-packard Company

Agilent Technologies, Inc.

Oc&eacute;-technologies B.v.

Merlin Lilliput Gmbh

Boehringer Ingelholm Microparts Gmbh

Ralf-Peter Peters

Gert Blankenstein

Holger Bartos

Eiad Kabaha

Holger Reinecke

Dirk Klaus Osterloh

Michael J Pugia

Stefan Miltenyi

Ying Yu

Nezih Unal

Frank Bartels

Christian Schoen

Wolfgang Stoeters

Friedolin Franz Noker

John Stuart Foster

Joachim Eicher

James Arthur Profitt

Manfred Berndt

Daryl Grummitt

Nicholas C Martinez

Christian Schön

Frederik Fritzsch

Mario Hempel

Christian Peth

Erich Zabler

Stephen Terence Dunne

Werner Uhler

Holger Holakovsky

Andreas Bosio

Andreas Baumann

Dirk Kurowski

Lloyd S Schulman

Jan Boddenberg

Claus Marquordt

Thomas Willms

Markus Nagel

Zeno Rummler

Raimund C Wyzgol

Franciscus J H M Van Den Beucken

Arnd Rogner

Werner Schomburg

Marc Paul Schuwer

Sven Ignatius

Anton Bruil

Dierk Landwehr

Ilse Ballhorn

Birgit Mueller-Chorus

Michael Schlueter

Dominik Hammerschmidt

Nezih Ünal

Martin Buscher

Herbert Backes

Holger Hollmann

Christian Vesper

Birgit Müller-Chorus

Juliane Stuth

Jan Keseberg

Werner Karl Schomburg

Wolfgang A Heyde

Lothar Heinrich

Dirk Osterloh

Martin BÜSCHER

Claus Dipl-Ing Marquordt

Wolfgang Dipl-Ing Stöters

Christian Dipl-Ing Vesper

Christian Schon

The invention is directed to a peristaltic pump (), comprising: a flexible membrane () forming a at least one bladder () against a support, wherein each bladder is provided with one input orifice () which admits a fluid to the bladder () and one outlet orifice () which releases the fluid from the bladder (); and at least one roller bearing () is configured to rotate about an axis () and to apply a compressive force against the at least one bladder (). The peristaltic pump may be in fluid communication with a tapered jet ().

Perestaltic pump and device for isolating cells from biological tissue

The invention is directed to a slide chamber comprising a top member (), a fluidic seal (), a transparent closure member () and base member () wherein the top member () is provided with at least one examination chamber () and a plurality of openings () positioned at two sides of the cover member outside of the examination chamber (); and the base member () is provided with interconnecting means () complementary to the openings () of the top member characterized in that the interconnecting means () of the base member () and the openings () of the top member () are configured to mechanically interlock with each other by lateral movement thereby pressing the top member () against the transparent closure () member in a water-tight manner.

Slide chamber

A multilevel, disposable cartridge may have a plurality of fluid wells or reservoirs holding a plurality of reagents, and a sample viewing area to view a biological sample. The reagents may be applied sequentially to the sample by opening a specific valve formed in an elastomeric, flexible layer under the fluid well. The fluid channels may be formed in a first rigid plastic layer to conduct the reagent to the sample. Pneumatic channels for applying suction or pressure to the valves may be formed in a second rigid, plastic layer.

Multilevel disposable cartridge for biological specimens

The invention is directed to disposable cartridge for electroporation of cells, comprising a fluid compartment in an interior of the disposable cartridge; a first fluid port for providing cell suspension to the fluid compartment, and a second fluid port for delivering a fluid comprising at least one compound to be electroporated into the cells to the fluid compartment; a first electrode and a second electrode disposed in the fluid compartment; at least one exit port which delivers the fluid from the fluid compartment wherein the first and second fluid port have a fluid communication to a mixing channel which has a fluid communication to the fluid compartment, and a third ground electrode and a fourth ground electrode.

Disposable cartridge for electroporation

The invention relates to an apparatus for separating blood and at the same time an apparatus () for absorbing blood () and separating components such as blood plasma, as a sample liquid (), having a feed device () for receiving the blood (), a separating device () for separating blood components as the sample liquid (), a channel () which takes up the sample liquid () preferably exclusively by capillary forces and a fill device for filling the channel () with sample liquid () in an inlet or feed region () of the channel (), wherein the separating device (), particularly a membrane, is domed, more particularly convexly shaped and projects with the apex of the convex shape into the filling device in the direction of filling.

Apparatus for the separation of plasma

The invention is directed to a centrifuge chamber comprising a cylinder having a base plate and a cover plate, a rotational axis with at least one port for input and/or output of liquids, at least one port for input of gases and at least one layer for cell culturing, wherein the layer for cell culturing comprises a gas-permeable membrane on which cells can be cultured and wherein the at least one port for input and/or output of gases is connected to the gas-permeable membrane.

Centrifugation chamber with gas permeable membrane layers for cell cultivation

The invention is related to a device for suspending particles in a fluid, wherein the mixing device includes a first magnet () rotating around a longitudinal axis (), a mixing rod () attached to a mount (), the mount including a second magnet (), wherein the mount () moves in a substantially orthogonal motion to the longitudinal axis of the mixing rod () by the interaction of the rotating first magnet with the second magnet ().

Method and device for suspending cells

A MEMS-based cell sorting system is disclosed, which uses a novel combination of features to accomplish the cell sorting in the microfabricated channels housed in a disposable cartridge. The MEMS-based cell sorting system may include a microfabricated cell sorting valve that is responsive to an applied magnetic field. The MEMS-based cell sorting system may further include an electromagnet that generates a magnetic field to actuate the microfabricated cell sorting valve. The electromagnet may have a design which allows it to create a very localized magnetic field while having adequate thermal properties to operate reliably.

Cell sorting system using electromagnetic solenoid

A MEMS-based cell sorter is disclosed, which uses a novel combination of features to accomplish the cell sorting using a microfabricated cell sorting valve housed in a disposable cartridge. The features include an interposer that provides fluid communication between the microfluidic passages in the silicon substrate and a plurality of fluid reservoirs in the cartridge, including a sample, sort and waste reservoir The disposable cartridge may include other features that assist in the handling of small volumes of fluids, such as a siphon region in the sort reservoir and funnel-shaped regions in the sample and waste reservoirs. A mixing mechanism may be provided for stirring the contents of the sample reservoir.

Cell sorting system using microfabricated components

A centrifuge chamber for separating a sample into at least two components, including a cylinder having a base plate and a cover plate, and a rotational axis assembly having at least one port for input and/or output of the sample, the port being connected to a tube located on or in the base plate and/or cover plate, and the tube having one or more openings into the centrifuge chamber, where at least one opening of the tube is provided with at least one flat-shaped deflector having a surface lying substantially parallel with the cylinder, and a width at its base of at most 1/10 of the inner circumference of the cylinder.

Centrifugation chamber with deflectors

The invention relates to an apparatus for separating blood, more particularly an apparatus () for absorbing blood () and separating blood components, e.g. blood plasma, as a sample liquid (). Said apparatus () comprises a feeding device () for absorbing the blood (), a device () for separating blood components as a sample liquid (), a duct which preferably absorbs the sample liquid () exclusively by means of capillary forces, and a device for filling the duct () with sample liquid () in an inlet or feeding zone () of the duct (). The separating device (), in particular a membrane, is curved, especially convexly shaped, and the apex of said curved, especially convex shape projects into the filling device.

The invention relates to a device and a method for cleaning sample material, in particular nucleic acids. The cleaning process takes place by means of centrifugal microfluidics and the invention provides a simple compact construction and a simple procedure. If necessary, the sample material is easily mixed with a solvent buffer and proteases in the device. The cleaned sample material is in particular transferred directly to a container. Separate containers for the removal of excess liquid are not required.

Device and method for treating or cleaning sample material, in particular nucleic acids

A micro-liter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved through one or more sample wells arrayed within a small flat chip via interconnecting capillary passageways. The passageways may be either hydrophobic or hydrophilic and may include hydrophobic or hydrophilic capillary stops.

Apparatus for precise transfer and manipulation of fluids by centrifugal and or capillary forces

Holding device for the arrangement of at least one optical component in front of a laser light source of a laser unit, including a first holding part to which at least one optical component is attached, the holding device furthermore including a second holding part which is attached to one part of the laser unit, and the first holding part being attached to the second holding part. Furthermore this invention relates to an arrangement with such a holding device and a process for producing this arrangement.

Device for the manipulation of limited quantities of liquids

The present invention relates to devices for efficient transport, transfer and movement of fluids. In particular, the invention provides fluidic micro-structures for controlled transport and movement of liquids in devices for analytical and other purposes. Devices of the invention include one or more features that can enhance performance of the fluid transfer, referred to as a pre-shooter stop, a butterfly structure, a cascade structure, a waste chamber inlet, a capillary driven sample inlet chamber, a capillary stop structure, a bifurcation flow-through structure, and a hydrophobic vent.

Structures for uniform capillary flow

Growing community of inventors

Bergisch-Gladbach, Germany

Ralf-Peter Peters