Giuliani S.p.a.

Curapel (scotland) Limited

Henkel Ag & Company, Kgaa

Nogra Pharma Limited

Cutaneon - Skin & Hair Innovations Gmbh

Ralf Paus

Sergio Baroni

Giammaria Giuliani

Francesca Viti

Salvatore Bellinvia

Barbara Marzani

Anna Benedusi

Catherine Anne O'Neill

Hanns Hatt

Stefan Müllner

Jeremy Cheret

Benedetto Grimaldi

Daniela Pinto

Yuval Ramot

Astrid Becker

Nathan Hawkshaw

Thomas Rouille

Edo Hoting

Chris Ward

Jeremy CHERÉT

Jérémy Cheret

The present invention relates to the use of iminooxothiazolidine derivatives for preventing or treating hair growth disorders. The iminooxothiazolidine derivatives may be formulated as compositions suitable for either the systemic administration or the local application to the scalp.

Composition for prevention and treatment of hair growth disorders

The present invention concerns the use of selected compounds in a cosmetic skincare treatment or in the treatment of certain skin, scalp or mucosal diseases. The invention also provides a composition for topical use incorporating a pharmaceutically or cosmetically effective amount of a compound for preventing or treating skin or mucosal diseases having an inflammatory component or for reducing the redness or irritation of skin or mucosae.

Compounds for preventing and treating skin or mucosal affections having an inflammatory component

The invention relates to a synergistic composition comprising a dry extract of plant of genusand a compound promoting autophagy selected from biotin and R-N1-spermidine or a salt thereof, wherein R is hydrogen or methyl and mixtures thereof. The synergistic compositions according to the invention may be in the form of a topical formulation or oral formulation and is useful as a promoter of autophagy especially in cells of human scalp hair follicles and in promoting hair growth and/or in the treatment of hair thinning or hair loss.

Synergistic composition as a promoter of autophagy

The invention concerns the use of compounds of general formula (I): (I) wherein: Rand Rform together a double bond, or Rand Rform together a cyclopropyl group; R, Rare the same or different and independently chosen from hydrogen, methyl, or Rand Rform together a double bond; R, R6 are the same or different and independently chosen from hydrogen, methyl; or Rand Rform together a double bond, or Rand Rform together a cyclopropyl group; R=methyl, or ethyl; R=hydrogen, or methyl, for promoting hair growth and/or inhibiting or delaying hair loss in the human scalp, and cosmetic and pharmaceutical compositions suitable for such use.

Compounds for promoting hair growth and/or inhibiting or delaying hair loss in humans, and compositions for such uses

Use of a non-digestible oligosaccharide or salt thereof for producing an anti proliferative effect in a subject wherein the non-digestible oligosaccharide is of formulae (i) [A]-[B]Formula 1 wherein A and B are each independently a five or six membered saccharide unit and n is 2 to 10.

Use of non-digestible oligosaccharides

The present invention provides cosmetic and pharmaceutical compositions and therapies capable of reducing skin pigmentation and valuable in treating and managing disorders of skin pigmentation. The invention uses safe and well tolerated non-digestible oligosaccharides as the active agents providing numerous advantages over the harsh chemicals of previously available compositions.

Cosmetic and pharmaceutical uses of saccharides

The invention concerns the use of compounds with formula (I) R&#x2014;N1-spermidine, or 1,4-butandiamin,N-(3-amino propyl)-N1-R, (I) HN&#x2014;(CH)&#x2014;N(R)&#x2014;(CH)&#x2014;NHeither as such or in the form of a pharmaceutically acceptable derivative, such as an active ingredient in a cosmetic composition designed to promote hair pigmentation, particularly the pigmentation of the shaft, and a composition suitable to achieve said pigmentation effect and containing said active ingredient, either as such or in the form of a pharmaceutically acceptable derivative such as a salt, for topical administration.

Composition for cosmetic use suitable to produce a pigmentation effect on hair

The present invention relates to a cosmetic or pharmaceutical composition for treating alopecia, and in general for counteracting excessive hair loss, comprising as an active ingredient a compound of formula (I) R&#x2014;N-spermidine, or 1,4-butane-diamine,N-(3-aminopropyl)-N&#x2014;R. The compounds of general formula (I) are active in accordance with the objects of the present invention, and also sufficiently stable to allow effective application for topical use on the scalp without potentially being transformed into a different substance, which is no longer active, as a result of oxidation.

Pharmaceutical or cosmetic composition for treating alopecia

The present invention relates to compounds having general formula (I):CH&#x2014;(CH&#x2550;CH)&#x2014;R&#x2003;&#x2003;(I)where: n=3, 5, 7; R is chosen from &#x2014;CH&#x2014;O&#x2014;CO&#x2014;R', &#x2014;CO&#x2014;OR&#x2032; or &#x2014;CO&#x2014;O,

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Hamburg, Germany

Ralf Paus