Zedira Gmbh

Novartis Ag

Trumpler Gmbh & Co. Chemische Fabrik

N-zyme Biotech Gmbh

Dr. Falk Pharma Gmbh

U-nica Technology Ag

N-zyme Biotec Gmbh

Ralf Pasternack

Martin Hils

Achim Müller

Monika Knuth

Jens Zotzel

Christine Reiff

Christian Büchold

Johannes Weber

Hans-Lothar Fuchsbauer

Uwe Gerlach

Rudolf Wilhelm

Roland Greinwald

Katharina Schmid

Norbert Hampp

Wolfgang Mohr

Katharina Nikolaus

Achim Mueller

Stefan Marx

Michael Meyer

Thomas Feigel

Heinz-Peter Germann

Arne Seitz

Manfred Palissa

Christine Reiff, Geb Schmitt

Kai Oertel

Dominik Jordan

Christian Buchold

Bernhard Tewes

Martin Stieler

Christian BÜCHOLD

H-L Fuchsbauer

The invention relates to a compound of general formula (I) as novel inhibitor of blood coagulation factor XIII, methods for synthesis thereof and to use thereof for the prophylaxis or treatment of diseases associated with blood coagulation factor XIII. 

Inhibitors of blood coagulation factor XIII

The invention relates to the compound of general formula (I) as novel inhibitors of transglutaminases, to methods for producing the inventive compounds, to pharmaceutical compositions containing said inventive compounds and to their use for the prophylaxis and treatment of diseases associated with transglutaminases.

Inhibitors of transglutaminases

The invention relates to pyridinone derivatives of general formula (I) as inhibitors of tissue transglutaminase, to methods for producing the pyridinone derivatives, to pharmaceutical compositions containing said pyridinone derivatives and to their use for the prophylaxis and treatment of diseases associated with tissue transglutaminase.

Derivatives of pyridinone as inhibitors for tissue transglutaminase

A process for the preparation of a beverage, a beverage base, a beverage concentrate or a beverage additive having a reduced prolamin content from prolamin-containing raw materials, comprising the following steps:

Prolamin-reduced beverages and methods for the preparation thereof

The present invention relates to the diagnosis of disorders or dysfunctions characterized by autoimmune responses to the enzyme class of transglutaminases. The present invention provides a novel open structure of the transglutaminases in a stabilized form which renders new epitopes accessible for antibody-binding.

Stabilized open form transglutaminase as a diagnostic indictor for autoimmune diseases

The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.

Method for coating silicone hydrogels

The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking the water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.

Process for the manufacture of a composite material

Described are a composition and process for the enzymatic tanning of hides utilizing one or more transglutaminases for crosslinking the collagen in the hide.

Agent and method for enzymatically tanning skins

Growing community of inventors

Griesheim, Germany

Ralf Pasternack