Universitaet Leipzig

Dr. Roland Berecz

Universitat Leipzig

Berecz, Roland

Ralf Mikut

Serge Ruden

Kai Hilpert

Ralf Hoffmann

Daniel Knappe

This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to composite and methods for destroying microorganisms, such as bacteria, viruses or fungi, and to methods for treating microbial infections. The object of the invention is to develop novel antibiotic peptides, particularly having enhanced antibiotic activity and an expanded spectrum of activity against other strains of bacteria, particularly gram-positive bacteria such as According to the invention, the object is attained in a first aspect by a peptide according to claim

Modified apidaecin derivatives as antibiotic peptides

This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to compositions and methods for destroying microorganisms, such as bacteria, viruses or fungi, and to methods for treating microbial infections. The object of the invention is to develop novel antibiotic peptides, particularly having enhanced antibiotic activity and an expanded spectrum of activity against other strains of bacteria, particularly gram-positive bacteria such as According to the invention, the object is attained in a first aspect by a peptide according to claim

The present invention is directed to the peptides WKWLKKWIK, WRKFWKYLK, and RRWRVIVKW and use of said peptides as therapeutic agents for the prophylaxis and/or treatment of infections, in particular bacterial and/or fungal infections and diseases caused by bacterial and/or fungal infections.

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Karlsruhe, Germany

Ralf Mikut