Greenovation Biotech Gmbh

Midatech Limited

Meridian Biopharmaceuticals Gmbh

Ralf Kircheis

Thomas William Rademacher

Hans Loibner

Manfred Schuster

Gilbert Gorr

Wolfgang Jost

Andreas Nechansky

Gottfried Himmler

Soledad Penades Ullate

Rafael Ojeda Martinez De Castilla

Günter Waxenecker

G C Mudde

Manuel Martin Lomas

Jose Luis De Paz Carrera

Africa Garcia Barrientes

Geert C Mudde

T Midatech Limited Rademacher

Helmut Eckert

The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.

Glyco-engineered antibodies

Nanoparticles comprising adjuvants and antigens, such as tumor and pathogen antigens, are disclosed and their use in a range of applications such as for the treatment of cancer and infectious diseases. Immunogenic structures based on nanoparticles or antibodies with carbohydrate ligands, and their use for therapeutic and prophylactic purposes, and for the isolation and detection of antibodies directed against the carbohydrate structures.

Nanoparticles comprising antigens and adjuvants, and immunogenic structures

The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that &#x2022; the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and &#x2022; at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.

Growing community of inventors

Vienna, Austria

Ralf Kircheis