Newsouth Innovations Pty Limited

Universitetet I Oslo

Vestlandets Innovasjonsseiskap as

Ewsouth Innovations Pty Limited

Vestlandets Innovasjonsselskap as

Ralf Kellmann

Brett A Neilan

Kjetill Sigurd Jakobsen

Russel J S Orr

Shauna Ann Murray

Troco Kaan Mihali

Young Jae Jeon

Anke Stuken

Anke Corinna Stüken

Russel J Orr

The present invention relates to processes to make neosaxitoxin, and analogues and variants thereof, and intermediates in the production of neosaxitoxin in recombinant host cells. Neosaxitoxin and the analogues and variants thereof may be used in the production of pharmaceutical compositions.

Processes to make neosaxitoxin and analogues thereof

The invention generally relates to the field of saxitoxins and the identification of microorganisms capable of producing them. More specifically, the invention relates to the identification of genes encoding saxitoxin in dinoflagellates, and methods for the specific detection of dinoflagellates that are producers of saxitoxins.

Detection of saxitoxin-producing dinoflagellates

Process

The present invention provides methods for the detection of cyanobacteria, and in particular, methods for the detection of cyanotoxic organisms. The invention further relates to methods of screening for compounds that modulate the activity of polynucleotides and/or polypeptides of the saxitoxin biosynthetic pathways.

Cyanobacteria saxitoxin gene cluster and detection of cyanotoxic organisms

The current disclosure generally relates to the field of saxitoxins and the identification of microorganisms capable of producing them. In particular, the saxitoxin A (sxtA) gene comprising catalytic domain sequences saxitoxin A1 (sxtA1) and saxitoxin A4 (sxtA4) is identified in a number of dinoflagellate species. The disclosure relates to methods of detection of saxitoxin-producing dinoflagellates by amplification and detection of the sxtA gene (in particular by PCR) and kits and primers for use in the method are also disclosed. Saxitoxin-producing dinoflagellate genera detected by the method includeor

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Nesttun, Norway

Ralf Kellmann