Harvard College

Dana-farber-cancer Institute Inc.

Ludwig-Maximilians-Universitat München

Xgenomes Corp.

Ralf Jungmann

Peng Yin

Xi Chen

Sarit Agasti

William M Shih

Mingjie Dai

Chenxiang Lin

Chao Li

Kalim U Mir

Cameron Myhrvold

Maier S Avendano Amado

Johannes Benedikt Woehrstein

Yonggang Ke

Diming Wei

Florian Schüder

Johannes B Wöhrstein

Maier Avendano

Johannes B Woehrstein

The present disclosure provides, inter alia, methods and compositions (e.g., conjugates) for imaging, at high spatial resolution, targets of interest.

Quantitative DNA-based imaging and super-resolution imaging

Provided herein are, inter alia, barcode probes comprised of transiently or stably fluorescently labeled nucleic acid nanostructures that are fully addressable and able to be read using standard fluorescent microscope and methods of use thereof including methods of use as detectable labels for probes.

Nucleic acid nanostructure barcode probes

The present invention relates to methods of determining the sequence of nucleotides in target nucleic acid molecules. Thus, the invention relates to methods of sub-unit sequencing. The methods comprise the use of identification nucleic acid detection entities which specifically hybridize to the target nucleic acid, bind identification tags and have localization tags transiently bind thereto.

Molecular identification with subnanometer localization accuracy

The present invention provides, inter alia, methods and compositions for imaging, at high spatial resolution, targets of interest.

High-throughput and highly multiplexed imaging with programmable nucleic acid probes

The invention provides SST motifs of controlled size and shape, comprised of a plurality of oligonucleotides, and methods for their synthesis. The motifs are formed, at least in part, by the self-assembly of single stranded oligonucleotides into curved, corrugated or twisted structures. The location of each oligonucleotide in the resultant motif is known. Accordingly, the motifs may be modified with specificity.

Compositions and methods relating to complex nucleic acid nanostructures

Growing community of inventors

Munich, Germany

Ralf Jungmann