Charite - Universitaetsmedizin Berlin

Charité – Universitätsmedizin Berlin

Ralf Hauptmann

Eyk Schellenberger

Jing Xie

Bernd Hamm

Monika Ebert

Matthias Taupitz

Susanne Wagner

Jörg Schnorr

Harald Kratz

Akvile Häckel

Angela Ariza De Schellenberger

Nicola Stolzenburg

Ines Gemeinhardt

Janni Breinl

Janna Glaeser

Akvile Haeckel

Joerg Schnorr

Janna Glaser

Monika Eber

Janna GLÄSER

The invention provides novel iron(III) complexes with formulae (1) and (2). Furthermore, corresponding ligands with formulae (L1) and (L2) for the production of iron(III) complexes are disclosed.

Iron(III) complexes having new contrast agent properties, for magnetic resonance imaging

A process is provided in which the resulting Fe-tCDTA contrast agent has a reduced osmolality. The process according to the invention comprises the following steps:

Method for preparing an Fe-tCDTA contrast agent and product obtainable by the method

The invention includes a substance based on nanocrystalline maghemite having a crystal size of between 0.5 and 4 nm, which is defined by a proportion of divalent iron ions less than five percent by weight of the total iron, and the transport of sodium and simultaneously phosphate in the gastrointestinal wall from the gastrointestinal contents into the bloodstream is reduced and thus can improve the imbalance of electrolyte and water and mineral balances of patients having impaired renal function when used orally in combination with suitable pharmaceutical adjuvants.

Drug based on maghemite for simultaneous reduction of gastrointestinal sodium resorption and phosphate resorption

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Berlin, Germany

Ralf Hauptmann