Phenox Gmbh

Covidien LP

Micro Therapeutics, Inc.

Femtos Gmbh

Charité – Universitätsmedizin Berlin

Ralf Hannes

Hermann Monstadt

Hans Henkes

Achim Flesser

Stefan Rolla

Manuel Salin

Jörg Ascherfeld

Elina Miloslavski

Carsten Aporta

Pervinder Bhogal

Volker Trösken

Manuel Schneider

Uwe Schedler

Christian Heise

Thomas Thiele

Tim Lenz-Habijan

Catrin Bannewitz

Manuel Salen

Diana Stateczny

Thomas Liebig

Elina Henkes

David Slattery

Ken Beatty

Dennis Herklotz

Dennis Germeroth

Holger Pracht

Fabian Dieste

Volker TRÖSKEN

A device () for removing thrombi from blood vessels, wherein the device () has an expanded state in which it is set free temporarily in the blood vessel and a compressed state in which it is introduced into and removed from the blood vessel through a microcatheter, wherein the device () has a proximal (), a middle () and a distal portion (), with the middle portion () having a substantially cylindrical structure and the proximal portion () being coupled to an insertion aid (), and the distal portion () having a substantially cylindrical basic structure, with a constriction () being arranged between the middle () and distal portion (), and the distal portion () being at least partially covered by a membrane (). The inventive device () is characterized by the fact that thrombus fragments becoming detached from the thrombus to be captured are safely retained and removed from the blood vessel.

Thrombectomy device

A device () for introducing endovascular implants (), which have an at least partially cylindrical design, into blood vessels, where the implant () is provided in an expanded state in which the implant is placed in the blood vessel, and in a compressed state, in which the implant can be introduced into the blood vessel, and the device () has an elongated shaft (), the exterior of which is releasably secured to the implant () in the compressed state and through which the implant () runs. The implant () has at least one respective connection point () to the shaft () proximally and distally, said connection point being thermally, chemically, or electrolytically releasable; or at least one thread () extends in the longitudinal direction over the implant () at least over a majority of the length of the implant () such that the implant () is secured to the shaft () in the compressed state, and the thread () has at least one respective connection point () to the shaft () proximally and distally, at least one connection point () of the connection points being thermally, chemically, or electrolytically releasable.

Device for introducing implants

A device for introducing an implant () into blood vessels or hollow organs of the human or animal body. The device includes an implant (), an insertion wire () and a release tube (), wherein the implant () is deformable so that it fits into a microcatheter () and expands once the external constraint of the microcatheter () disappears, adapting to the diameter of the blood vessel or hollow organ, wherein a holding element () is arranged on the insertion wire () and the holding element () has at its periphery at least one groove () set into the holding element (), running along the circumference of the holding element () and forming tracks in the form of curved lines, wherein the implant () has holding wired () extending proximally, which are fitted into the grooves ().

Implant insertion system

A medical device substrate with a coating including a functional layer located on the substrate, with the functional layer including at least one sugar alcohol and being bonded to the substrate directly or indirectly via a functionalization of the sugar alcohol. Alternatively, the functional layer may also include other saccharides, in which case it is essential that polymerization of the saccharides takes place only upon bonding to the substrate. The inventive medical device exhibits reduced platelet adhesion and aggregation.

Coating for medical devices

The invention relates to a device () having a stent structure () intended for the insertion into blood vessels of the human or animal body, wherein the stent structure () assumes an expanded state during which it is in contact with the inner wall of the blood vessel and a contracted state during which the stent structure being located in a microcatheter can be moved through the blood vessel, wherein the stent structure () preferably being connected at its proximal end with an delivery wire () and wherein the device () being employed for the treatment of vasospasm. Moreover, the invention also relates to a relevant method for the treatment of vasospasm.

Vasospasm treatment

The invention relates to a device for the introduction of an implant () into blood vessels of the human body, said device comprising an implant (), a pusher or insertion wire (), and a tube-like sheathing (), wherein the implant () is capable of being deformed inside a microcatheter in a manner that allows it to assume a shape of reduced diameter and, after omission of such external constraint exerted by the microcatheter, expand at the placement site and adapt to the blood vessel diameter, and wherein the implant () being provided at the proximal end with connection elements () attaching it to a retaining element () by means of which the implant () is coupled to the pusher wire (), and wherein the retaining element () is provided with peripheral cutouts () into which the connecting elements () are fitted, with the tube-like sheathing () being drawn in a form-closed manner over the retaining element () with fitted connection elements () such that the connection elements () are secured within the cutouts () of the retaining element () and the implant () being released by the retraction of the tube-like sheathing () in proximal direction, with the outer diameter of the tube-like sheathing () varying between the proximal and the distal end. In this manner, high pliability is achieved in some sections of sheathing () which is conducive to maneuvering through narrow blood vessels, and, moreover, sufficient tensile strength is available for the purpose of releasing implant ().

Insertion and release system for implants

The invention relates to an implant for vascular applications that can be transported by means of a catheter and is intended in particular to influence the blood flow in the area of arteriovenous malformations, such as fistulas and aneurysms, to fill the saclike dilation of the malformation, promote thrombus formation and cover the neck of the malformation. The implant according to the invention is provided with an occlusion unit () having a three-dimensional shape constructed from several subunits () from a framework of struts (), with a covering, preferably a membrane (), being located between struts ().

Band-shaped occlusion means

An occlusive implant for bifurcation aneurysms (A), with the implant () being in an expanded state in which it is implanted in the blood vessel and in a contracted state in which it is movable through the blood vessel, with the implant () having a proximal fixing section () by means of which the implant () can be secured to the wall of a blood vessel, a distal section () where the implant () in expanded state is radially widened relative to the fixing section () and which is intended for placement in or in front of the aneurysm (A), and having a transition section () located between the fixing section () and the distal section (), wherein fixing section () is attached to an delivery wire () in a detachable manner and wherein the transition section () has a second detachment point () which enables the distal section () to be detached.

Implant having a detachable mechanism

A catheter () comprising an elongate tubular body () having a proximal end (), a distal end (), and an inner lumen () extending through the elongate tubular body (), wherein the elongate tubular body () comprises a proximal section () and a distal section (), wherein at least the proximal section () comprises at least two layers, wherein the proximal end () is connected with a catheter hub () being an adapter of greater radial outside dimension than the elongate tubular body (), wherein the catheter hub () has an inner lumen () of larger inside diameter than the elongate tubular body (), and wherein the innermost layer () of the proximal section () extends into the catheter hub () and flares from the proximal section () to the catheter hub (). The catheter ensures a smooth transition of a medical device, e.g. a stent to be transferred from a storage device like a sheath into the tubular body of the catheter.

Catheter with catheter hub

An implant () to be used for the occlusion of bifurcation aneurysms, with the implant () having an expanded state in which it is implanted in the blood vessel (Z) and a contracted state in which it is movable through the blood vessel (Z) and a proximal fixing section () a distal section () where the implant () is radially widened relative to the fixing section () and which is intended for placement in or in front of the aneurysm (A), and a transition section () located between the fixing section () and the distal section (), wherein the implant (). The implant is composed of interconnected or intersecting filaments () originating from the fixing section () or distal section () which meet centrally in the transition section (), wherein the filaments () in the transition section () at least to some extent pass through a sleeve ().

Vascular implant

The invention relates to a membrane implant for the treatment of vascular malformations, said implant being implantable by endovascular methods into the vessel to be treated, wherein the membrane implant consists of an expandable stent () and a membrane () connected with the stent (), with said membrane () covering the meshes of the stent () at least in a central region, wherein said membrane () is provided in the form of a non-woven fabric comprising plastic fibrils, and the membrane () forms an integral bond with the stent () and, at least partially, is of porous design.

Implant comprising a non-woven fabric

The invention relates to a thrombectomy device with a substantially cylindrical stent structure (), which has a multiplicity of meshes () and two connectors (') that are arranged on different meshes () at the proximal end of the stent structure (), and with a guide wire (), which has a coupling element () to which the connectors (&#x2032;) are coupled, with a slit (), which extends in a helical formation across the jacket surface () of the stent structure (), and with a tensioning bow (), which spans the slit () at the proximal end.

A blood vessel implant to influence the flow of blood in the area of arteriovenous malformations. The implant has a wall of individual filaments forming a tubular braiding extending axially from the proximal to the distal end, the individual filaments crossing and forming points of intersection. The implant is deformable so that in an insertion catheter it is shaped so that its diameter is reduced and can be expanded at the implantation site adapting to the diameter of the blood vessel. The filament ends at the proximal and/or distal end of the braiding are each brought together at least in pairs and connected with each other permanently. The filament ends connect with each other and are shaped so as to be atraumatic The filaments cross at the points of intersection distally from the filament ends and are connected with each other at the proximal end of the implant.

Implant for influencing the blood flow in arteriovenous defects

The invention relates to a device having an endovascular implant () for the introduction into blood vessels or body cavities of the human or animal body and an insertion aid (), wherein the implant () and the insertion aid () being connected to each other via a detachment element () designed to be electrolytically corrodible so that after the implant () has been inserted into the body and a voltage has been applied an at least partial dissolution of the detachment element () takes place causing the implant () to be separated from its the insertion aid (), with the detachment element () being made of a cobalt-chrome alloy containing at least 20% w/w cobalt and 10 to 40% w/w chrome.

Growing community of inventors

Dortmund, Germany

Ralf Hannes