Westfaelische Wilhelms-universitaet Muenster

Scv Spezial-chemikalien-vertriebs Gmbh

Telix Pharmaceuticals Limited

Helmholtz-zentrum Dresden-rossendorf E.v.

Westfalische Wilhelms-universität Münster

Ralf Bergmann

Luisa De Cola

Frank Rösch

Nils Engelbogen

Lukas Greifenstein

Holger Stephan

Luisa DeCola

Alexander Ruffani

The invention relates to a marking precursor incorporating a chelator or fluorination group for radiolabelling with 44Sc, 47Sc, 55Co, 62Cu, 64Cu, 67Cu, 66Ga, 67Ga, 68Ga, 89Zr, 86Y, 90Y, 90Nb, 99mTc, 111ln, 135Sm, 140Pr, 159Gd, 149Tb, 160Tb, 161Tb, 165Er, 166Dy, 166Ho, 175Yb, 177Lu, 186Re, 188Re, 213Bi and 225Ac or with 18F, 131I or 211At, and one or two biological targeting vectors which are coupled to the chelator or fluorinating group via one or more squaric acid groups.

Marking precursor with squaric acid coupling

The invention relates to a marking precursor incorporating a chelator or fluorination group for radiolabelling withSc,Sc,Co,Cu,Cu,Cu,Ga,Ga,Ga,Zr,Y,Y,Nb,Tc,In,Sm,Pr,Gd,Tb,Tb,Tb,Er,Dy,Ho,Yb,Lu,Re,Re,Bi andAc or withF,I orAt, and one or two biological targeting vectors which are coupled to the chelator or fluorinating group via one or more squaric acid groups.

Labeling precursors with squaric acid coupling

The present invention is related to silicon nanoparticles, a pharmaceutical composition comprising silicon nanoparticles, a method for synthesis of the silicon nanoparticles and their use for in vivo diagnostics, visualization of drug delivery or staining of cells, biological processes or pathways. The silicon nanoparticles are characterized that they comprise a silicon core of a size of 1 to 10 nm and are terminated with allylamine or poly(allylamine) comprising up to 10 allylamine groups.

Functionalised silicon nanoparticles

Growing community of inventors

Dresden, Germany

Ralf Bergmann