Arizona State University

Johns Hopkins University

Rakesh Paul

Sidney M Hecht

Sandipan Roy Chowdhury

Rumit Maini

Larisa (Liza) Dedkova

Manikandadas Mathilakathu Madathil

Chandrabali Bhattacharya

Michael James Rishel

Marc M Greenberg

Trevor Bozeman

Zhiqiang Yu

Chenhong Tang

Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.

Ribosome-mediated incorporation of peptides and peptidomimetics

Methods and compounds are disclosed for irreversibly inhibiting a DNA repair enzyme that possesses lyase activity.

DNA polymerase beta inhibitors

This invention relates to compounds comprising a saccharide conjugated to an imaging agent or a reporter group, compositions comprising them and methods of using them. Specifically BLM-disaccharide and BLM-monosaccharide conjugates containing different linker groups and an imaging agent or a reporter group are provided for the targeting and imaging of tumors.

Saccharide conjugates

The present disclosure relates to sugar-linker-drug conjugates, of the formula [A-B-]n-L-D, wherein A is a saccharide; B is a spacer, n is an integer selected from 1 to 3; L is a linker group and D is a drug having a chemically reactive functional group selected from the group consisting of a primary or secondary amine, hydroxyl, sulfhydryl, carboxyl, aldehyde and ketone. Pharmaceutical compositions comprising the conjugates and methods of using them are also provided.

Sugar-linker-drug conjugates

Growing community of inventors

Baltimore, MD, United States of America

Rakesh Paul