Women & Infants Hospital of Rhode Island

University of Rochester

Brown University

Uwm Research Foundation, Inc.

Women & Infants' Hospital

Women and Infants' Hospital Rhode Island

Other

Louisiana State University and Agricultural & Mechanical College

Woman & Infants' Hospital of Rhode Island

Rakesh Kumar Singh

Richard Garrett Moore

Laurent Brard

Satyan Kalkunte

Kyu Kwang Kim

Alexander E Arnold

Preetpal Singh Sidhu

Premchendar Nandhikonda

Giselle L Saulnier Sholler

Narasimha Swamy

Robert Michael Strongin

Onur Alpturk

Kyu K Kim

Rachael Turner

Deepak Sahasrabudhe

Giselle Saulnier-Sholler

Naohiro Yano

Stayan Kalkunte

Hema Malini Sundaresha

Laurant Brard

The present disclosure provides novel compounds, compositions, and methods for modulating one or more septin proteins, e.g., septin-2. Such compounds and compositions are useful for the treatment of a cancer, e.g., endometrial, pancreatic, lung, breast or ovarian cancer, such as serous and ovarian clear cell carcinoma.

Septin inhibitors for treatment of cancers

The present disclosure relates to compounds and methods for treating cancer, the methods comprising administering to the subject a compound of formula (1). In some embodiments, the disclosure provides compounds and methods for inhibiting IQGAP1.

Compounds and methods for the treatment of acute myelogenous leukemia

The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method of preparing compounds of the invention, or a salt or solvate thereof.

7-dehydrocholesterol derivatives and methods using same

Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a proliferating cell for treatment with a cytotoxic agent via inhibiting expression of HE4 and one or more immune checkpoint inhibitors (ICIs). Also provided herein are methods for determining whether a subject who has been diagnosed with cancer would benefit from immunotherapy as well as methods for determining whether a subject with cancer is responding to immunotherapy via assessment of levels of HE4 gene and/or protein expression.

Therapy for malignant disease

Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating cancer in a subject, and for inhibiting angiogenesis in a subject.

Vitamin D receptor-coregulator inhibitors

Provided are computer implemented methods and systems for structuring information of email messages. An exemplary method comprises receiving an incoming email message. An automatic response is sent to a sender of the incoming email message with a request for information. The requested information is received from the sender and associated with a bin. The bin is structured according to a data model associated with the bin.

Methods and systems for structuring information of email messages

The invention provides compositions and methods for utilizing human epididymal secretion protein E4 (HE4) in the prevention and treatment of cancer and other human diseases.

HE4 based therapy for malignant disease

The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.

Nitrofuran compounds for the treatment of cancer and angiogenesis

The present invention relates to adamantyl derivatives and their anti-cancer activity. Compounds of formulae I and II are provided as well as related methods of treatment and methods of synthesis.

Adamantyl derivatives as therapeutic agents

This invention relates to the design, synthesis and use of synthetic vitamin D and other steroidal analogs. It further relates to the therapeutic use of such analogs and their manufacture.

Heterocycles and derivatives thereof and methods of manufacture and therapeutic use

The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds. 

Growing community of inventors

Barrington, RI, United States of America

Rakesh Kumar Singh