The United States of America, As Represented by the Secretary, Department of Health and Human Services

Kite Pharma, Inc.

Rajul Jain

Steven A Rosenberg

James Noble Kochenderfer

Adrian I Bot

Jeffrey S Wiezorek

William Go

Ruben Alvarez Rodriguez

Eric H Gschweng

Yong Ouyang

Margo Roberts

The invention provides methods of increasing the efficacy of a T cell therapy in a patient in need thereof. The invention includes a method of conditioning a patient prior to a T cell therapy, wherein the conditioning involves administering a combination of cyclophosphamide and fludarabine.

Methods of conditioning patients for T cell therapy

The invention provides methods of increasing the efficacy of a T cell therapy in a patient in need thereof. The invention includes methods of identifying a patient who would respond well to a T cell therapy or conditioning a patient prior to a T cell therapy so that the patient responds well to a T cell therapy. The conditioning involves administering one or more preconditioning agents prior to a T cell therapy and identifying biomarker cytokines prior to administering a T cell therapy.

Diagnostic methods for T cell therapy

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Santa Monica, CA, United States of America

Rajul Jain