Other

Chiron Corporation

Rajsharan K Rana

Bao-lu Chen

Robert F Halenbeck

Kirk William Johnson

Maninder S Hora

Glenn J Dorin

Gary V Johnson

Hassan Madani

Mark E Gustafson

Bo H Arve

Michael Tsang

Gregory L Pattison

Gary S Bild

Maninder S Hoba

A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.

Method of solubilizing, purifying, and refolding protein

Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.

TFPI formulation

Growing community of inventors

Woodinville, WA, United States of America

Rajsharan K Rana