Ankh Life Sciences Limited

Rajni Verma

Gene H Zaid

Krishna Mohan Donavalli

Beth Ann Wolf

Rachel Elizabeth Ropp

Low-temperature syntheses of thymoquinone/harmaline compounds which are useful for the treatment of human diabetes and cancers, and the derivatives, solvates, prodrugs, isomers, and tautomers of such compounds.

Low-temperature synthesis of thymoquinone and harmaline compounds

Methods for the synthesis of harmine comprise reacting harmaline with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in the presence of a diacid catalyst. In an embodiment, the synthesis is carried out using a reaction mixture of harmaline, DDQ, THF solvent, and succinic acid; the reaction is carried out under an inert atmosphere with refluxing for a period of 4-12 hours.

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Wichita, KS, United States of America

Rajni Verma