Medtronic Minimed, Inc.

Percusense, Inc.

Alfred E. Mann Foundation

Alfred E. Mann Foundation for Scientific Research

Medtronic Minmed, Inc.

Raghavendhar, Gautham

Wolfe, Katherine T.

Liang, Bradley Chi

Shah, Rajiv

Little, Megan E.

Rajiv Shah

Rebecca K Gottlieb

Raghavendhar Gautham

Bradley Chi Liang

Michael E Miller

Katherine T Wolfe

Shaun M Pendo

Bahar Reghabi

Wayne A Morgan

Gopikrishnan Soundararajan

Udo Hoss

Ning Yang

David Choy

Joseph H Schulman

Peter G Schultz

Jenn-Hann Larry Wang

James L Henke

Yanan Zhang

Eric Allan Larson

Kenneth W Cooper

Charles L Byers

Xiaolong Li

Yiwen Li

Keith Nogueira

Bradley J Enegren

John Joseph Mastrototaro

Ronald J Lebel

Lu Wang

Ellen K Messer

John Charles Gord

Timothy J Starkweather

Barry Keenan

Lyle Dean Canfield

Edward Chernoff

William P Van Antwerp

Nannette M Van Antwerp

Joseph Y Lucisano

Mike C Liu

Brian T Kannard

Soren Aasmul

Andy Y Tsai

Taly G Engel

Megan E Little

Jaeho Kim

Jesper Svenning Kristensen

Barry P Pham

Anubhuti Bansal

Eric A Grovender

Rudy Montalvo

Qingling Yang

Anirban Roy

Ying Luo

Daniel E Pesantez

Aaron Swanson

Jennifer M Reynolds

Ratnakar Vejella

Eunjoo Jin

Mary M Morris

Cary D Talbot

Andrea Varsavsky

Yuxiang Zhong

Michael Steven Colvin

Pratik J Agrawal

Varaz Shahmirian

Richard E Purvis

Chia-Hung Chiu

Ashwin K Rao

Tri T Dang

John C Mueller, Jr

Steven C Jacks

Paul Citron

Brooks B Cochran

Catherine M Szyman

Joseph Ferreira

Ly Phou

Konrad Chan

Victor Giron

Yunbing Wang

Scott Robert Gibson

Benyamin Grosman

Zhongping C Yang

Randal C Schulhauser

Robert C Mucic

Desmond Barry Keenan

Mohsen Askarinya

Garry M Steil

Larry Earl Tyler

Charles R Gordon

Jeffrey Nishida

Henrik Egesborg

Richard S Yoon

Rudolph A Montalvo

Kris R Holtzclaw

Fei Yu

Heath A Jensen

James D Holker

Dongjuan Chris Xi

Gayane R Voskanyan

Joseph P Brinson

A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods

In one embodiment, a sensor is disclosed that includes a first conductive substrate coupled to, and electrically isolated from, a second conductive substrate. The sensor includes a first electrode trace within the first conductive substrate with a plurality of first working electrode openings. The sensor also includes a second electrode trace within the first conductive substrate with a plurality of second working electrode openings. Additionally a first transport material is included that covers the plurality of first working electrode openings and a second transport material that covers the plurality of second working electrode openings. A third transport material covers, and forms a barrier between the first and the second transport material. The sensor additionally includes a counter-reference electrode that is formed on the second conductive substrate.

Analyte sensor

Sensing and infusion devices are described. In one embodiment, a sensing and infusion device may include an implantable segment having a sensor. The sensing and infusion device may also include a catheter, and a sensor channel may be formed in the catheter. The sensor channel may be configured to retain at least a portion of the implantable segment.

In Vivo sensing and infusion devices

A sensor assembly is disclosed. The sensor assembly includes a piercing member with an interior and exterior. Also included within the sensor assembly is a sensor that is formed on a flexible substrate. The sensor includes a proximal end and a distal end where the distal end includes a flex that is terminated at a terminal end. The terminal end of the sensor being located within the interior of the piercing member.

Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

Sensor systems, devices, and methods for continuous glucose monitoring

A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic—cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

Method of and system for stabilization of sensors

A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body.

Orthogonally redundant sensor systems and methods

In vivo sensing and infusion devices

An on-body insertion system is described. The on-body system includes a sensor in a first position being substantially parallel to an insertion surface. Activation of an actuator transitions the sensor to a second position. Wherein the transition imparts movement to the sensor that is substantially parallel to the insertion surface and the second position results in the sensing area being beneath the insertion surface.

Sensor insertion

An introducer is provided for introducing a sensor into the body of a patient. The introducer connects to a sensor hub. When the sensor hub and introducer are connected, the introducer needle is exposed. When the sensor hub and introducer are disconnected, a needle cover and the needle move with respect to each other so that the needle cover substantially covers the needle, protecting a user from being injured by the needle.

Needle protective device for subcutaneous sensors

An electrode measuring the presence of an analyte is described as one embodiment. The electrode includes a working conductor with an electrode reactive surface and a first reactive chemistry that is responsive to the analyte. The electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry and a second transport material that supplies a reactant to the first reactive chemistry. Wherein the first reactive chemistry does not contact the electrode reactive surface while at least partially shadowing a portion of the electrode reactive surface.

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Rancho Palos Verdes, CA, United States of America

Rajiv Shah