Igen, Inc.

Micro Vesicular Systems, Inc.

Micro-pak, Inc.

Prime Pharmaceutical Corporation

Rajiv Mathur

Donald F Wallach

Nadya Lawrence

Robert G Mills

Paul A Tremblay

An-Cheng Chang

Jean Philippot

Surendra Kumar

S Esmail Tabibi

Elizabeth C Albert

Sheryl L Henderson

A skin treatment composition comprising aextract in a liposome delivery system is described. Theextract is present in the skin treatment composition in a range of from 5% to 20% by weight of the total composition. The skin treatment composition is particularly effective in the treatment of psoriasis, eczema and other dry skin conditions. A process for obtaining an extract ofis also disclosed.

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A skin treatment composition comprising aextract in a liposome delivery system. Theextract is present in the skin treatment composition in a range of from 5% to 20% by weight of the total composition. The skin treatment composition is particularly effective in the treatment of psoriasis, eczema and other dry skin conditions. The invention further provides a process for obtaining an extract of

Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same

Liquid energy sources, e.g., liquid fuels comprising lipid vesicles having fuel additives such as water are disclosed herein. The liquid energy sources, methods for preparation, and methods of enhancing engine performance disclosed herein employing the lipid vesicles result in enhanced fuel efficiency and/or lowered engine emissions. The invention further relates to liquid energy sources containing such additives which further comprise a polymeric dispersion assistant, which reduces the interfacial tension and coalescence of vesicles during dispersion process and storage, and thereby provide transparent looks to the liquid energy source.

Lipid vesicle-based fuel additives and liquid energy sources containing same

A fluid preparation of petrolatum capable of being sprayed on to a surface. The preparation includes paucilamellar lipid vesicles containing the petrolatum. Preferably, petrolatum comprises about 20-30% or more of the total weight of the vesicles. Methods of protecting the skin of mammals using the fluid preparation of petrolatum are also discussed.

Methods, uses and compositions of fluid petrolatum

Paucilamellar lipid vesicles containing lipid bilayers at least two lipid bilayers formed of surfactant materials, each of the bilayers comprising a glucoside primary amphiphile and a steroid. The vesicles may have either an aqueous or oil-filled central cavity and are particularly useful for delivering dermatological, cosmetic and pharmaceutical formulations. A method of manufacture for these vesicles is also disclosed.

Glucoside paucilamellar vesicles

The invention features a method of stabilizing free 1-ascorbic acid from oxidation by dispersing the free 1-ascorbic acid in a mixed glycol carrier and a solution containing the ascorbic acid in the mixed glycol solution. The mixed glycol carrier contains a mixture of at least propylene glycol and butylene glycol, but may contain other glycols such as polyethylene glycol, and stabilizing and solubility assisting agents as well.

Stabilized vitamin C formulations

The invention features a method of stabilizing free 1-ascorbic acid from oxidation by dispersing the free 1-ascorbic acid in a mixed glycol carrier and a solution containing the ascorbic acid in the mixed glycol solution. The mixed glycol carrier contains a mixture of at least propylene glycol and butylene glycol, but may contain other glycols such as polyethylene glycol , and stabilizing and solubility assisting agents as well.

Lipid vesicle-based fuel additives and liquid energy sources containing

A reduced fat chocolate preparation comprising lipid vesicles is disclosed. Also disclosed is a method of manufacturing the reduced fat chocolate preparation. The chocolate has less fat than regular chocolate and a higher percentage of water.

Reduced fat chocolate and method of manufacture

Lipid vesicles which remain stable at high temperatures are disclosed. The vesicles contain as a component of their lipid bilayers at least one ethoxylated alcohol having a linear C20-C50 carbon chain. Also disclosed is a method of making the vesicles. The lipid vesicles are useful in forming cosmetic and dermatologic preparations, such as lipstick, which are processed at high temperatures (e.g., at 80.degree. C. or above) during manufacture.

Heat resistant lipid vesicles

Disclosed are oil-filled paucilamellar lipid vesicles containing at least one non-phospholipid amphiphile as the primary lipid of the vesicle bilayers and avocado oil unsaponifiables. The vesicles are particularly useful for delivering dermatological, cosmetic and pharmaceutical formulations. A method of manufacture for these vesicles is also disclosed.

Lipid vesicles containing avocado oil unsaponifiables

An antacid product having extended duration of residence in the gastric and upper intestinal systems has been developed. This antacid product includes a blend of 10-70% by volume nonphospholipid lipid vesicles, with a particulate base. An antiflatulence agent may also be included. A method of providing extended duration amelioration of acid build up in the gastric and upper intestinal tract using this product is also disclosed.

Extended duration antacid product

Disclosed are lipid vesicles containing a blend of amphiphiles, including propylene glycol stearate, in the lipid bilayers. The vesicles may have either an aqueous or oil-filled central cavity and are particularly useful for delivering dermatological, cosmetic and pharmaceutical formulations. A method of manufacture for these vesicles is also disclosed.

Propylene glycol stearate vesicles

Disclosed are lipid vesicles containing a blend of amphiphiles, including sucrose distearate, in the lipid bilayers. The vesicles may have either an aqueous or oil-filled central cavity and are particularly useful for delivering dermatological, cosmetic and pharmaceutical formulations. A method of manufacture for these vesicles is also disclosed.

Sucrose distearate lipid vesicles

A new class of lipid vesicles having a blend of two lipids, a primary lipid and a secondary lipid, has been developed. The primary lipid, which forms the greatest proportion of lipid by weight, will not form vesicles nor preferably, even a lamellar phase, without addition of the secondary lipid. Preferably primary lipids are C.sub.12 -C.sub.18 fatty alcohols, C.sub.12 -C.sub.18 glycol monoesters, and C.sub.12 -C.sub.18 glyceryl mono- and diesters.

Growing community of inventors

Sewell, NJ, United States of America

Rajiv Mathur