Mayo Foundation for Medical Education and Research

Rajiv Kumar

Sanjay Misra

Jan Van Deursen

Jennifer J Westendorf

Zachary C Ryan

Theodore A Craig

This document provides methods and materials for reducing development of stenosis of arteriovenous fistulas. For example, methods and materials for reducing IEX-1 polypeptide expression or activity within a mammal (e.g., a human) to reduce venous neointimal hyperplasia and/or the development of stenosis of arteriovenous fistulas are provided.

Methods and materials for reducing development of stenosis of arteriovenous fistulas

The present disclosure provides a prostacyclin coated implant to enhance fracture repair and bone formation comprising: an implant; and a prostacyclin coating comprising a prostacyclin compound disposed in a polymer coating the implant, wherein the prostacyclin coating releases the prostacyclin compound which enhances fracture repair and bone formation.

Prostacyclin compositions for regulation of fracture repair and bone formation

The invention provides methods and materials related to animals having a disrupted IEX-1 sequence. For example, the invention provides homozygous knockout (IEX-1) animals and heterozygous (IEX-1) animals.

IEX-1 knockout animals

An isolated and purified DNA sequence encoding hemangioma factor-1 is provided. A host cell transformed with a DNA sequence encoding hemangioma factor-1 and a method of introducing and expressing the DNA sequence in a host cell is also provided. A further embodiment of the invention is an expression cassette comprising the isolated and purified DNA sequence encoding hemangioma factor-1.

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Rochester, MN, United States of America

Rajiv Kumar