Genentech, Inc.

Rajita Khosla

Philip E Hass

Menno Van Lookeren Campagne

Gerald R Nakamura

Meredith C Hazen

Wenwu Zhai

Dhaya Seshasayee

Nancy Chiang

Yi-Chun Hsiao

Jack Bevers, Iii

Hongkang Xi

Tracy Staton

Joseph R Arron

Brian Yaspan

Amy Dressen

David Choy

Vladimir Ramirez-Carrozzi

The invention provides interleukin-33 (IL-33) antibodies and methods of using the same.

Anti-interleukin-33 antibodies and uses thereof

The invention relates to methods of treating a patient suffering from an IL-33-mediated disorder, such as asthma, comprising administering to the patient an IL-33 axis binding antagonist based on the genotype of the /L1RL1gene, the genotype of a polymorphism in genomic vicinity to the IL-33 gene, the expression level of periostin or the expression level of soluble ST2. The invention further relates to methods of determining whether a patient is at increased risk of an IL-33-mediated disorder, as well as methods of determining whether a patient suffering from such a disorder is likely to respond to a treatment comprising an IL-33 axis binding antagonist, based on the genotype of the /L1RL1gene the genotype of a polymorphism in genomic vicinity to the IL-33 gene, the expression level of periostin or the expression level of soluble ST2.

Therapeutic and diagnostic methods for IL-33-mediated disorders

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Foster City, CA, United States of America

Rajita Khosla