Lupin, Inc.

Les Laboratoires Servier

Rajinder Singh Siyan

Girij Pal Singh

Gurvinder Pal Singh

Himanshu Madhav Godbole

Nandu Baban Bhise

Rajendra Dagesing Mahale

Debashish Datta

Pankaj Ramchandra Chaudhari

Sukhdeo Sampat Gunjal

Sunil Kumar Vinubhai Gohel

Raju Muktaji Walunj

Anurag Trivedi

The present invention provides process for preparation of cysteamine bitartrate comprising reacting cysteamine or its salt with tartaric acid. The present invention further provides crystalline form L1 of cysteamine bitartrate having characteristic diffraction peaks at 10.36, 14.54, 17.23, 18.03, 19.24, 20.76, 21.20, 22.02, 23.37, 23.64, 27.71, 28.28, 29.26, 31.33, 32.84, 33.83, 35.51, 36.74&#xb1;0.2 degree two theta in an X-ray diffraction pattern and process for preparation thereof. The present invention provides crystalline form L2 of cysteamine bitartrate having characteristic diffraction peaks at 7.4, 10.3, 11.0, 11.4, 14.4, 14.9, 18.6, 19.4, 20.1, 20.8, 21.9, 22.3, 22.5, 23.5&#xb1;0.2 degree two theta in an X-ray diffraction pattern and process for preparation thereof.

Process for preparation of cysteamine bitartrate

An improved process for synthesis of duloxetine hydrochloride (1) having chiral purity greater than 99.9% that is characterized by the following:

Process for preparation of duloxetine hydrochloride

A process for preparation of perindopril of formula (II) and salts thereof which is simple, safe, convenient and cost-effective.    

Process for preparation of perindopril and salts thereof

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Pune, India

Rajinder Singh Siyan