Novartis Ag

Emisphere Technologies, Inc.

Arena Pharmaceuticals, Inc.

Other

Rajesh K Agarwal

Simon David Bateman

Michael M Goldberg

Joseph Ault

Joseph Sikora

Rebecca F Yang

Joseph Zielinski

Kiran Chaudhary

Subash Patel

Shingai Majuru

Moise Azria

JoAnne P Corvino

William Elliot Bay

William Lucas Betts, Iii

Yuan-Hon Kiang

James A Henshilwood

Noah Post

William Elliott Bay

Thomas J Slaga

Jifu Zhao

Brian Slaga

Shingai Majura

JoAnne P Russo

Mosise Azria

Joanne P Russo

Joseph Murray Ault

Joseph L Zielinski

Rebecca Fai-Ying Yang

The present invention is directed to crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, compositions containing the same and uses thereof.

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Crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-thtrahydro-1H-3-benzazepine hydrochloride

The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. Preferred delivery agents include, but are not limited to, N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC), N-(10-[2-hydroxybenzoyl]amino)decanoic acid (SNAD), and sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC). The invention also provides methods of preparing the disodium salt, ethanol solvate, and hydrate and compositions containing the disodium salt, ethanol solvate, and/or hydrate.

Disodium salts, monohydrates, and ethanol solvates for delivering active agents

The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein

The present invention is directed to crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, compositions containing the same, preparations, and uses thereof.

A process for increasing the levels of polyphenolic acid release into coffee which is brewed from beans which are bathed in an aqueous sodium bicarbonate solution shortly after roasting. The same process is applied to other polyphenolics containing beverage substrates, including teas. The bathing of beverage substrates (coffee beans and tea leaves, for example) with the aqueous sodium bicarbonate does not adversely change the taste of the produced beverage, and, in fact, in the case of coffee, such process actually extends the apparent freshness of coffee by inhibiting in the condensation of tannins in the coffee brew, thereby providing, not only the health benefits of the elevated levels of polyphenols, but a means to extend the freshness of the brewed beverage.

Method for promoting extraction of beneficial compounds into beverages naturally containing same, and for extending the duration of freshness of coffee

Growing community of inventors

San Diego, CA, United States of America

Rajesh K Agarwal