Council of Scientific and Industrial Research

Other

Rajendra Singh Bhakuni

Sushil Kumar

Dharam Chand Jain

Atul Prakash Kahol

Suman Preet Singh Khanuja

Ram Prakash Sharma

Sudeep Tandon

Tarun Kumar Singh

Amit Tewari

Ajit Kumar Shasany

Madan Mohan Gupta

Ram Kishor Verma

Guru Prakash Dutta

Mahendra Pandurang Darokar

Ram Asrey Vishwakarma

Anil Kumar Singh

Raj Kishori Lal

Asish Kumar Bhattacharya

Ravi Prakash Bansal

Shiv Kumar Gupta

Anil Kumar Gupta

Govind Ram

Sudhanshu Saxena

Suman P S Khanuja

Shilpi Paul

Anuraddha Kumar

Sundeep Tandon

Neerja Pant

Mohammed Shafique Siddique

Shubhra Rastogi

Pallavi Yadav

Syed Uzma Jalil

The present invention relates to the development of high viridiflorol containing variety for enhancing the aroma as well as medicinal properties ofby overexpressing MPTPS4 gene through genetic transformation. This transgenic plant possesses better growth and able to produce essential oil with good quality contains high viridiflorol maximum of about 25% and proportionate decrease in menthone, menthofuran and menthol ofas compared to other control genotype.(CIM-madhuras) that produces viridiflorol, a molecule of potential demand in perfumery, cosmetics, toiletries, drugs and sanitation products.

Method for increasing viridiflorol content in tissues

The present invention is related to the development of a novel, distinct high herb and artemisinin yielding genotype ofobtained through systematic marker assisted breeding followed by selection of uniform population in a methodical way wherein the genotype is distinct, uniform and stably maintainable by continuous rouging of off types in the population using DNA marker at early seedling stage from nursery itself and suitable for commercial cultivation.

High artemisinin yielding artemisia plant named 'CIM-arogya'

The present invention provides a method for the preparation of arteether from artemisinin in one pot in just about 4 hours comprising reduction of artemisinin into dihydroartemisinin by less quantity of sodium borohydride in ethanol at room temperature in the presence of a novel polyhydroxy catalyst, acylation of dihydroartemisinin in the presence of an acid catalyst, extraction of arteether from an aqueous reaction mixture using 1% ethyl acetate in n-hexane followed by workup and purification of the impure arteether to yield 80-86% (w/w) pure alpha, beta arteether.

Single pot conversion of artemisinin into arteether

The present invention relates to an improved method for the preparation of Artemether. Artemether prepared from the process is useful for the treatment of uncomplicated, severe complicated and multi drug resistant malaria.

Single pot conversion of artemisinin into artemether

The present invention provides a single pot process for the preparation of artesunic acid from artemisinin involving reduction followed by esterification of the reduced product at room temperature.

Single pot conversion of artemisinin to artesunic acid

The present invention relates to a synergistic formulation useful for the control of wide spectrum of malarial infections, which comprises a pharmaceutically effective amount of dihydroartemisinin and a vegetable oil.

Process for the preparation of a formulation of dihydroartemisinin for the control of wide spectrum of malaria

The invention relates to an improved process for the preparation of arteether. The process comprises dissolving dihydroartemisinin in dry ethanol, adding a solid acid catalyst with trialkylorthoformate in the reaction mixture, stirring the reaction mixture at room temperature, adding H O to the reaction mixture, extracting the reaction product with a non-polar organic solvent, and drying the solvent over anhydrous sodium sulphate and evaporating the solvent to obtain pure arteether.

Process for the preparation of arteethers from dihydroartemisinin

The invention relates to a process for the isolation of compound scopoletin which is used as nitric oxide synthesis inhibitor from and other plant families, said process comprising extraction of dried powdered material of different plant parts with an aqueous acetonitrite solvent in the ratio of 1:5 for 6 to 8 hrs., concentration of the extracted solvent upto 30% of its original extract under vacuum, partitioning the concentrated extract with halogenated solvent to transfer scopoletin in the non-polar halogenated solvent, drying halogenated solvent over anhydrous sodium sulphate and evaporating the solvent, crystallizing the residues in methanol and filtering the crystals, concentrating the filtrate and chromatographed on silica gel, eluting scopoletin in chloroform methanol mixture; and crystallization of the fractions containing the scopoletin to get the pure scopoletin compound.

Process for the isolation of compound scopoletin useful as nitric oxide synthesis inhibitor

Formulation of dihydroartemisinin for the control of wide spectrum of malaria

This invention relates to a novel process for the dual production of essential oil and artemisinin from the plant Artemisia annua, said process comprising extracting the plant with hexane, partitioning the hexane extract between hexane and acetonitrile, hydrodistillation of hexane residue and Marc to yield essential oil, further fractionation of acetonitrile solvent between hexane-benzene mixture to remove artemisinic acid, chromatographing of the acetonitrile phase to produce substantially pure artemisinin, the artemisinic acid is reduced to obtain dihydro artemisinic acid which is then oxidised in a single step to form artemisinin.

Process for the simultaneous production of artemisnin and essential oil

Growing community of inventors

Lucknow, India

Rajendra Singh Bhakuni